201804-19-5Relevant articles and documents
Chiral ligand-controlled catalytic asymmetric epoxidation of α,β-unsaturated carbonyl compounds with peroxide
Tanaka, Yoshihito,Nishimura, Katsumi,Tomioka, Kiyoshi
, p. 4549 - 4556 (2007/10/03)
Asymmetric epoxidation reaction of α,β-unsaturated carbonyl compounds with alkylperoxide was catalyzed by an external chiral tridentate aminodiether-lithium peroxide giving epoxides with good enantiomeric excess. Slow addition of alkylhydroperoxide was beneficial for a catalytic asymmetric reaction. Lone pair electron-differentiating coordination of a carbonyl oxygen to lithium is another critical factor for high enantioselectivity.