201804-23-1

Basic information

• Product Name: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester
• Synonyms: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester
• CAS NO: 201804-23-1
• Molecular Weight: 375.489
• Mol File: 201804-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester(201804-23-1)
• EPA Substance Registry System: (2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester(201804-23-1)

Safety Data

• Hazardous Substances Data: 201804-23-1(Hazardous Substances Data)

Upstream product

• 201804-19-5 1-((2R,3S)-4-methoxyphenyloxiranyl)-2,2-dimethylpropan-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 2419-67-2 (E)-1-(4-methoxyphenyl)-4,4-dimethylpent-1-en-3-one 
• 137-07-5 2-amino-benzenethiol 
• 201804-22-0 tert-butyl (2R,3S)-3-(4-methoxyphenyl)glycidate 

Downstream Products

• 33286-22-5 diltiazem hydrochloride 
• 75472-91-2 (2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride 
• 42399-49-5 (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 

Relevant articles and documents

Improved procedure for Julia-Colonna asymmetric epoxidation of α,β-unsaturated ketones: Total synthesis of diltiazem and Taxol side-chain

Poly-L-leucine catalyses the asymmetric epoxidation of enones 1-6 efficiently in a non-aqueous medium to provide the epoxy ketones 7-12 (70-91% yield; 80 to ≥95% ee). The strategy was used to make diltiazem 16 and the Taxol side chain 23 in single enantiomer form.