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FMOC-D-ALANINOL, also known as 9H-Fluoren-9-ylmethyl N-tert-butoxycarbonyl-D-alaninate, is a chemical compound that serves as a crucial reagent in organic synthesis. It is a derivative of D-alanine, a naturally occurring amino acid, combined with the FMOC group, a prevalent protecting group for amines in organic chemistry. FMOC-D-ALANINOL is distinguished by its ability to facilitate the synthesis of peptides and other organic molecules, with the FMOC group being easily removable to expose the free amine group of the D-alanine residue. FMOC-D-ALANINOL holds significant importance in the realm of chemical synthesis and is extensively utilized in research and industrial applications.

202751-95-9

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202751-95-9 Usage

Uses

Used in Pharmaceutical and Biochemical Research:
FMOC-D-ALANINOL is used as a reagent for the synthesis of peptides and other organic molecules, facilitating the creation of complex molecular structures. Its role is pivotal in the development of new drugs and the study of biological processes, as it allows for the controlled assembly of amino acids into specific sequences.
Used in Organic Synthesis:
In the field of organic synthesis, FMOC-D-ALANINOL is used as a protected amino acid derivative, enabling chemists to carry out reactions that would otherwise be challenging due to the reactivity of the amine group. The FMOC group serves as a temporary shield, protecting the amine during the synthesis process and allowing for selective reactions to occur.
Used in Peptide Synthesis:
FMOC-D-ALANINOL is used as a building block in the stepwise assembly of peptides. The FMOC group's ease of removal makes it an ideal choice for solid-phase peptide synthesis, a technique widely used in the production of pharmaceuticals and other peptide-based compounds.
Used in Chemical Education:
FMOC-D-ALANINOL is utilized as an educational tool in teaching laboratories, where students learn about the principles of organic synthesis, the use of protecting groups, and the synthesis of peptides and other biomolecules.
Used in Industrial Production:
In the chemical and pharmaceutical industries, FMOC-D-ALANINOL is used in the large-scale production of peptides and other organic compounds. Its versatility and the efficiency of the FMOC protecting group make it a preferred choice for industrial applications requiring high yields and purity of the final product.

Check Digit Verification of cas no

The CAS Registry Mumber 202751-95-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,7,5 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 202751-95:
(8*2)+(7*0)+(6*2)+(5*7)+(4*5)+(3*1)+(2*9)+(1*5)=109
109 % 10 = 9
So 202751-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H19NO3/c1-12(10-20)19-18(21)22-11-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,12,17,20H,10-11H2,1H3,(H,19,21)/t12-/m1/s1

202751-95-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 9H-fluoren-9-ylmethyl N-[(2R)-1-hydroxypropan-2-yl]carbamate

1.2 Other means of identification

Product number -
Other names Fmoc-D-Alaninol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:202751-95-9 SDS

202751-95-9Relevant articles and documents

LEFT-HANDED GAMMA-PEPTIDE NUCLEIC ACIDS, METHODS OF SYNTHESIS AND USES THEREFOR

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Paragraph 0019; 00108; 00109, (2015/11/27)

A method of making optically pure preparations of chiral γΡΝΑ (gamma peptide nucleic acid) monomers is provided. Nanostructures comprising chiral γΡΝΑ structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed γΡΝΑ, and vice- versa, are provided.

An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator

Nagendra,Madhu,Vishwanatha,Sureshbabu, Vommina V.

experimental part, p. 5059 - 5063 (2012/09/22)

A simple and efficient method for the synthesis of alcohols from the corresponding carboxylic acids is described. Activation of carboxylic acid with 1-propane phosphonic acid cyclic anhydride (T3P) and subsequent reduction of the intermediate phosphonic anhydride with NaBH4 yield the alcohol in excellent yields with good purity in less duration. Reduction of several alkyl/aryl carboxylic acids and Nα-protected amino acids/peptide acids as well as Nβ-protected amino acids was successfully carried out to obtain corresponding alcohols in good yields and the products characterized. The procedure is mild, safe, simple and the isolation of the products is easy.

A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

Jadhav, Sandip V.,Bandyopadhyay, Anupam,Benke, Sushil N.,Mali, Sachitanand M.,Gopi, Hosahudya N.

supporting information; experimental part, p. 4182 - 4187 (2011/06/28)

A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated in high yields. The conformations in crystals of β-amino alcohol, dipeptide and tripeptide alcohols were analysed, with a well-defined type III β-turn being observed in the tripeptide alcohol crystals. This method is found to be compatible with Fmoc-, Boc- and other side-chain protecting groups.

Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3

Mandal, Pijus K.,Ren, Zhiyong,Chen, Xiaomin,Xiong, Chiyi,McMurray, John S.

experimental part, p. 6126 - 6141 (2010/03/24)

In cancer cells, signal transducer and activator of transcription 3 (Stat3) participates in aberrant growth, survival, angiogenesis, and invasion signals and is a validated target for anticancer drug design. We are targeting its SH2 domain to prevent docking to cytokine and growth factor receptors and subsequent signaling. One of the important elements of the recognition sequence, pTyr-Xxx-Xxx-Gln, is glutamine. We incorporated novel Gln mimics into a lead peptide, pCinn-Leu-Pro-Gln-NHBn, and found that a linear, unconstrained side chain and carboxamide are necessary for high affinity, and the benzamide can be eliminated. Replacement of Gln-NHBn with (R)-4-aminopentanamide or 2-aminoethylurea produced inhibitors with equal or greater potency than that of the lead, as judged by fluorescence polarization (IC50 values were 110 and 130 nM, respectively). When Pro was replaced with cis-3,4- methanoproline, the glutamine mimic, (4R,5S)-4-amino-5-benzyloxyhexanamide resulted in an IC50 of 69 nM, the highest affinity Stat3 inhibitor reported to date. 2009 American Chemical Society.

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