20469-89-0

Basic information

• Product Name: 2-Bromoisobutyrylchloride
• Synonyms: 2-broMo-2-Methyl propionyl chloride;Propanoyl chloride,2-broMo-2-Methyl;α-broMoisobutyric acid chloride;2-Bromo-2-methylpropanoyl chloride;alpha-Bromoisobutyryl chloride
• CAS NO: 20469-89-0
• Molecular Formula: C₄H₆BrClO
• Molecular Weight: 185.45
• EINECS: 1312995-182-4
• Mol File: 20469-89-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 60-75℃ (23 Torr)
• Flash Point: 44.1±19.8℃
• Appearance: /
• Density: 1.594±0.06 g/cm3 (20℃ 760 Torr)
• CAS DataBase Reference: 2-Bromoisobutyrylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromoisobutyrylchloride(20469-89-0)
• EPA Substance Registry System: 2-Bromoisobutyrylchloride(20469-89-0)

Safety Data

• Hazardous Substances Data: 20469-89-0(Hazardous Substances Data)

Usage

Uses

2-Bromo-2-methylpropanoyl Chloride is used as a reactant in the study on synthesis and process optimization of photoinitiator MMMP.

Upstream product

• 2052-01-9 2-bromo-2-methylpropionic acid 
• 79-30-1 isobutyryl chloride 

Downstream Products

• 23426-63-3 2-bromo-2-methylpropionic acid methyl ester 
• 100976-99-6 4-(α-bromo-isobutyryl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 908572-86-1 N-(α-bromo-isobutyryl)-L-tyrosine ethyl ester 
• 7462-74-0 2-bromo-2-methylpropanamide 
• 51368-55-9 isopropyl 2-bromo-2?methylpropanoate 
• 25228-61-9 2-Bromo-2-methyl-N-(3-propionylamino-phenyl)-propionamide 
• 25256-24-0 2-Bromo-N-(3-isobutyrylamino-phenyl)-2-methyl-propionamide 
• 25256-37-5 2-Bromo-N-[3-(2-bromo-2-methyl-propionylamino)-phenyl]-2-methyl-propionamide 
• 69635-74-1 2-bromo-2-methyl-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide 
• 138611-62-8 S-phenyl 2-bromo-2-methyl(thiopropanoate) 
• 189324-13-8 2-hydroxyethyl 2-bromoisobutyrate 
• 29443-17-2 3-Bromo-1-phenyl-3-methyl-butanon 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 

Relevant articles and documents

Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice

Peroxisome proliferator-activated receptors are promising therapeutic targets for metabolic diseases, including obesity, diabetes, and dyslipidemia. This study describes the design, synthesis and pharmacological evaluation of stilbene-based compounds as d

Method for synthesizing netarsudil intermediate

The invention relates to a method for synthesizing a netarsudil intermediate that is 6-aminoisoquinoline. The method includes (1) dissolving 2-bromo-2-methylpropionic acid; (2) adding oxalyl chloride,and then reacting the mixture; (3) after the reaction is completed, pouring the reaction solution into aqueous ammonia, stirring the mixture, performing filtration and drying a product. The method utilizes conventional and easily available chemical materials, and has characteristics of mild reactions, a short route and a high yield.

Synthesis method for alectinib hydrochloride intermediate

The invention discloses a synthesis method for an alectinib hydrochloride intermediate. The synthesis method includes the following steps: 1) with 2-bromo-2-methylpropionic acid as an initial raw material, adding thionyl chloride to perform a chlorination reaction to obtain a compound (I); 2) adding ethylbenzene to the compound (I) and adding anhydrous aluminum trichloride as a catalyst to perform a substitution reaction to obtain a compound (II); 3) dissolving the compound (II) in an organic solvent, adding HC(OMe)3 and a catalyst ZnCl2, performing heat reflux until a rearrangement reaction is completely finished to obtain a compound (III); 4) dissolving the compound (III) in an organic solvent, adding iodine and iodic acid to perform a catalytic reaction to generate a compound (IV); and 5) under alkaline condition, hydrolyzing the compound (IV) to produce the target product, alectinib hydrochloride intermediate. The synthesis method is simple in operations, has high yield and is lower in cost.