2050-92-2 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 2050-92-2 differently. You can refer to the following data:
1. colourless liquid
2. Diamylamine is a relatively strong base and forms salts with acids. Its vapors can
form explosive mixtures with air.
Uses
Different sources of media describe the Uses of 2050-92-2 differently. You can refer to the following data:
1. Di-n-amylamine is manufactured from amyl chloride and
ammonia. It is used in organic syntheses and as a solvent,
rubber accelerator, flotation reagent, and corrosion
inhibitor.
2. Dipentylamine was used in the synthesis of new melt-spinnable polymeric precursor to boron nitride ceramic fibers. It was used to compose background electrolyte for the separation of linear alkylbenzene sulfonates by nonaqueous capillary electrophoresis. It was employed as organic additive in the synthesis of pure AlP04-H2 (aluminophosphate material).
Production Methods
Diamylamine is manufactured by the same processes as n-amylamine by reaction
of amyl chloride with ammonia and then separated from the amylenes and amyl
alcohol by steam distillation (Hawley 1977). It also can be synthesized by
amination of alkyl halides at high temperature and pressure (Schweizer et al 1978).
The commercial product may be a mixture of amyl isomers (HSDB 1989).
General Description
A clear colorless liquid with an ammonia-like odor. Very slightly soluble in water. Density 6.40 lb / gal (less than water) Vapors heavier than air. Flash point 152°F. Difficult to ignite. Moderately toxic. Contact with liquid may cause a chemical burn. Vapors may irritate respiratory tract. Used in the manufacture of rubber, resins, and dyes.
Air & Water Reactions
Flammable. Sensitive to air and heat. Slightly soluble in water.
Reactivity Profile
Diamylamine neutralizes acids to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Health Hazard
Different sources of media describe the Health Hazard of 2050-92-2 differently. You can refer to the following data:
1. TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
2. Diamylamine is a strong eye, skin, and respiratory irritant owing to its basicity
(HSDB 1989). Vapor exposure results in irritation of the nose and throat with
distressed breathing and coughing. Prolonged exposure may lead to pulmonary
edema. Direct skin contact can cause secondary burns.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Industrial uses
Diamylamine is less widely used than n-amylamine with only 20 tons being
manufactured in the U.S. in 1976. Its most widespread use is as a corrosion
inhibitor and rubber accelerator (Hawley 1977). It is also useful as a solvent for
oils, resins, and some cellulose esters. Introduction of the amyl group imparts oil
solubility to otherwise oil-insoluble substances. Diamylamine also is used in
flotation reagents, dyestuffs and as a cockroach repellent (HSDB 1989).
Safety Profile
Poison by inhalation,
ingestion, and skin contact. A severe skin
irritant. See also AMINES. Flammable
liquid when exposed to heat or flame; can
react with oxidizing materials. To fight fire,
use alcohol foam, foam, CO2, dry chemical.
When heated to decomposition it emits
toxic fumes of NOx.
Metabolism
In contrast to n-amylamine, little information is available on diamylamine metabolism,
particularly with respect to its suitability as a substrate for the amine
oxidases. Generally, the rate of oxidation of secondary amines by monoamine
oxidase is slower than that of primary amines (Beard and Noe 1981). In agreement,
Yamada et al (1965) demonstrated that crystalline amine oxidase prepared
from Aspergillus niger oxidized diamylamine very slowly with respect to n-amylamine.
As with other secondary aliphatic amines, the propensity of diamylamine to
form nitrosamines is of interest. It has been shown that treatment of diamylamine
with nitrous acid in dilute aqueous solution gave optimum nitrosamine formation
between pH 1 and 3, corresponding to stomach conditions (Sander et al 1968).
When rats were fed a diet supplemented with sodium nitrite and secondary amines
of low basicity, synthesis of nitrosamines in the stomach was observed. Malignant
tumors arising through formation of nitrosamines in the stomach was demonstrated
only when nitrite was present in the stomach concomitantly with secondary
amines which readily formed carcinogenic nitrosamines.
Check Digit Verification of cas no
The CAS Registry Mumber 2050-92-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,5 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2050-92:
(6*2)+(5*0)+(4*5)+(3*0)+(2*9)+(1*2)=52
52 % 10 = 2
So 2050-92-2 is a valid CAS Registry Number.
2050-92-2Relevant articles and documents
Hydrogenation of Aliphatic Nitriles to Primary Amines over a Bimetallic Catalyst Ni25.38Co18.21/MgO–0.75Al2O3 Under Atmospheric Pressure
Shi, Dongxu,Zhu, He,Han, Yaping,Zhang, Yuecheng,Zhao, Jiquan
, p. 2784 - 2794 (2021/02/03)
Abstract: A mixed oxide supported bimetallic catalyst Ni25.38Co18.21/MgO–0.75Al2O3 was readily prepared and found to be efficient in the hydrogenation of valeronitrile (VN) to amylamine (AA) under atmospheric pressure. Under the optimal conditions: H2 to VN molar ratio of 4:1, NH3 to VN molar ratio of 3:1, reaction temperature of 130?°C and residence time of 5?s, the conversion of VN reached 100% with a AA yield of 70.8%, and a diamylamine (DAA) yield of 25.9%. This catalyst was also active in the hydrogenation of other low carbon aliphatic nitriles to their corresponding primary amines. The characterization results revealed that the catalyst had the properties of large surface area, uniform and fine dispersion of metal particles in the form of Ni/Co alloy with synergy effect between the two metals, which endowed the catalyst with good catalytic performances in the hydrogenation reaction of aliphatic nitriles. Graphic Abstract: [Figure not available: see fulltext.]
Hydrogenolysis of Amide Acetals and Iminium Esters
Kadyrov, Renat
, p. 170 - 172 (2017/12/26)
Amide acetals and iminium esters were hydrogenated into amines under very mild reaction conditions over common hydrogenation catalysts. This finding provides a new strategy for the selective reduction of amides. The synthetic utility of this approach was demonstrated by the selective reduction of amides bearing ester and nitrile groups.
Continuous Production of Dialkylamines by Selective Hydrogenation of Nitriles on a Nickel-Zeolite Catalyst
Popov, Yu. V.,Mokhov,Latyshova,Panov,Pletneva, M. Yu.
, p. 1778 - 1782 (2018/03/21)
Hydrogenation of aliphatic nitriles in the presence of nickel supported by NaX zeolite was studied. The data obtained were used to develop a continuous method for obtaining dialkylamines with the yield of the target product of up to 98%.
