2051-97-0Relevant articles and documents
Synthesis of a poly(ethylene glycol)-supported tetrakis ammonium salt: A recyclable phase-transfer catalyst of improved catalytic efficiency
Benaglia, Maurizio,Cinquini, Mauro,Cozzi, Franco,Tocco, Graziella
, p. 3391 - 3393 (2002)
The immobilization of four quaternary ammonium groups on a poly(ethylene glycol) support provided an efficient and recyclable phase-transfer catalyst.
Pyrrole synthesis using a tandem Grubbs' carbene-RuCl3 catalytic system
Dieltiens, Nicolai,Stevens, Christian V.,Vos, David De,Allaert, Bart,Drozdzak, Renata,Verpoort, Francis
, p. 8995 - 8998 (2004)
A straightforward pyrrole synthesis from diallylamines is developed by using a tandem catalyst system leading to ring-closing metathesis with the second generation Grubbs' catalyst (10%) followed by dehydrogenation in the presence of RuCl3 × H2O (2%).
A new method to N-arylmethylenepyrroles from N-acylpyrroles
D'Silva, Claudius,Iqbal, Rifat
, p. 457 - 458 (1996)
An efficient general method for the preparation of N-arylmethylenepyrroles based on the reduction of N-acylpyrroles is reported. The reduction procedure described is sufficiently mild to make it applicable to a variety of sensitive acyl and heterocyclic acyl compounds where reduction results in cleavage of the C-N bond. The method can also be used in the preparation of pyrrole derivatives containing base sensitive protecting groups.
Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons
Ban, Kazuho,Sajiki, Hironao,Sawama, Yoshinari,Yamamoto, Yuta
supporting information, p. 3898 - 3902 (2020/06/03)
3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.
Sulfoxide-Promoted Chlorination of Indoles and Electron-Rich Arenes with Chlorine as Nucleophile
Ji, Yuan-Zhao,Li, Hui-Jing,Wang, Yi-Ruo,Wu, Yan-Chao,Zhang, Zheng-Yan
supporting information, (2020/02/05)
An efficient chlorination of indoles and electron-rich arenes with chlorine anion as nucleophile is described. With the use of ethyl phenyl sulfoxide as the promoter, the reaction went smoothly under metal-free and mild conditions. Various indoles and electron-rich arenes are converted into the corresponding chlorinated compounds in moderate to excellent yields. A plausible interrupted Pummerer reaction mechanism was proposed without the oxidation of chloride anion. In addition, the byproduct thioether could be easily converted to the starting material sulfoxide just by a simple oxidation reaction. (Figure presented.).
Anti-inflammatory COX/LOX inhibitor, and preparation method and application thereof
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Paragraph 0054-0056, (2019/04/10)
The invention provides an anti-inflammatory COX/LOX inhibitor, and a preparation method and an application thereof. The inhibitor is a compound represented by formula I, or a pharmaceutically acceptable salt thereof. The novel anti-inflammatory COX/LOX inhibitor can significantly reduce the ear swelling degree of mice in an administrated group in xylene-induced ear swelling test, so the compound has an anti-inflammatory effect, and the anti-inflammatory effect of the compound is equivalent with that of aspirin; and additionally, pharmacological tests show that the compound has small irritationto the gastrointestinal tract. The preparation method of the novel anti-inflammatory COX/LOX inhibitor has the advantages of simplicity, easiness in operation, and effectiveness in the reduction of the production cost to realize industrial production.
