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2065-75-0

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2065-75-0 Usage

Chemical Properties

Light Yellow Solid

Uses

Used in the formation of glyoxal-derived adducts from substituted guanines

Check Digit Verification of cas no

The CAS Registry Mumber 2065-75-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,6 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2065-75:
(6*2)+(5*0)+(4*6)+(3*5)+(2*7)+(1*5)=70
70 % 10 = 0
So 2065-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H3BrO2/c4-3(1-5)2-6/h1-3H

2065-75-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H31030)  Bromomalonaldehyde, 97%   

  • 2065-75-0

  • 1g

  • 534.0CNY

  • Detail
  • Alfa Aesar

  • (H31030)  Bromomalonaldehyde, 97%   

  • 2065-75-0

  • 5g

  • 1682.0CNY

  • Detail
  • Alfa Aesar

  • (H31030)  Bromomalonaldehyde, 97%   

  • 2065-75-0

  • 50g

  • 2728.0CNY

  • Detail
  • Alfa Aesar

  • (H31030)  Bromomalonaldehyde, 97%   

  • 2065-75-0

  • 250g

  • 7920.0CNY

  • Detail

2065-75-0Relevant articles and documents

Honeybourne

, p. 49 (1978)

BSA binding and antibacterial studies of newly synthesized 5,6-Dihydroimidazo[2,1-b]thiazole-2-carbaldehyde

Yallur, Basappa Chanabasappa,Katrahalli, Umesha,Krishna, Panchangam Murali,Hadagali, Manjunatha Devagondahalli

, (2019)

A new heterocyclic compound, 5,6-Dihydroimidazo[2,1-b]thiazole-2-carbaldehyde (ITC) was synthesized and its antibacterial activity and also its interaction with bovine serum albumin (BSA) were studied. The structure of the synthesized compound was confirmed by 1H NMR, 13C NMR and IR spectroscopic techniques. The antibacterial activity was carried out by minimum inhibitory concentration (MIC) method. The compound showed a good antibacterial activity. The mechanism of interaction between the BSA and ITC under physiological conditions was investigated by various molecular spectroscopic techniques like, fluorescence, circular dichroism (CD), UV absorption and FT-IR. The interaction between ITC and BSA was followed by studying the quenching of intrinsic fluorescence of BSA upon the addition of ITC at three different temperatures. The binding constant (K), Stern-Volmer quenching constant (Ksv) and number of binding sites were determined. The separation distance between BSA and ITC was evaluated based on the fluorescence resonance energy transfer theory. The conformational changes in BSA upon binding of ITC were also confirmed. The interference of some metal ions on interaction was studies. The displacement studies with site specific markers confirm that the site III was the binding site for ITC on BSA.

Method for synthesizing 5-bromo-7-azaindole

-

Paragraph 0019; 0027-0028, (2019/06/07)

The invention provides a method for synthesizing 5-bromo-7-azaindole, and belongs to the field of medicinal chemical synthesis. The method comprises the following steps: reacting a raw material 1,1,3,3-tetramethoxypropane 2 with bromine to obtain an intermediate 3, preparing an intermediate 4 from an intermediate 3 under the action of an alkali, and reacting the intermediate 4 with 2-aminopyrroleto obtain the 5-bromo-7-azaindole 1. The method has the advantages of few reaction steps, easily available raw materials, high yield, small pollution, and easiness in amplified production.

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema

Inoue, Takayuki,Morita, Masataka,Tojo, Takashi,Yoshihara, Kousei,Nagashima, Akira,Moritomo, Ayako,Ohkubo, Mitsuru,Miyake, Hiroshi

, p. 1219 - 1233 (2013/03/28)

Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammatory diseases, including diabetes complications such as macular edema. In our VAP-1 inhibitor program, structural modifications following high-throughput screening (HTS) of our compound library resulted in the discovery that thiazole derivative 10, which includes a guanidine group, shows potent human VAP-1 inhibitory activity (IC50 of 230 nM; rat IC 50 of 14 nM). Moreover, compound 10 exhibited significant inhibitory effects on ocular permeability in STZ-induced diabetic rats.

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