207290-72-0

Basic information

• Product Name: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde
• Synonyms: 5-(4-Hydroxypiperidino)-2-Thio;5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde;2-Formyl-5-(4-hydroxypiperidin-1-yl)thiophene, 1-(5-Formylthien-2-yl)-4-hydroxypiperidine;5-(4-hydroxypiperidin-1-yl)thiophene-2-carbaldehyde;5-(4-Hydroxy-1-piperidinyl)-2-thiophenecarboxaldehyde
• CAS NO: 207290-72-0
• Molecular Formula: C10H13NO2S
• Molecular Weight: 211.28
• Product Categories: Piperidine;Thiophene intermediates
• Mol File: 207290-72-0.mol

Chemical Properties

• Melting Point: 137-139°
• Boiling Point: 417.8 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 9.97E-08mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.77±0.20(Predicted)
• CAS DataBase Reference: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(207290-72-0)
• EPA Substance Registry System: 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde(207290-72-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 207290-72-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde is used as a synthetic intermediate for the development of pharmaceutical compounds. Its structural features, including the hydroxy group and the aldehyde functionality, make it a versatile building block in the creation of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde serves as a key intermediate. Its presence of reactive functional groups allows for further chemical reactions, facilitating the synthesis of complex organic molecules for various purposes, including but not limited to specialty chemicals and materials.
Used in Industrial Processes:
Although further research is required, 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde may find applications in various industrial processes. Its potential use could be in the development of new materials, catalysts, or as a component in chemical reactions that are part of larger industrial syntheses.

InChI:InChI=1/C10H13NO2S/c12-7-9-1-2-10(14-9)11-5-3-8(13)4-6-11/h1-2,7-8,13H,3-6H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 912287-56-0 (Z)-2-(3,4-dimethoxy-phenyl)-3-[5-(4-hydroxy-piperidin-1-yl)-thiophen-2-yl]-acrylonitrile 

Relevant articles and documents

Efficient synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution in water

We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to

A facile synthesis of 5-N, N-bis(2-hydroxyethyl)amino-2- thiophenecarboxaldehyde

Amination of 5-bromo-2-thiophenecarboxaldehyde with an acyclic secondary amine - bis(2-methoxyethyl)amine was effected by using weak base sodium bicarbonate. The resulting 5-N,N-bis(2- methoxyethyl)amino-2-thiophenecarboxaldehyde was treated with boron tribromide to give 5-N,N-bis(2-hydroxyethyl)amino-2- thiophenecarbox-aldehyde.

Synthesis of high molar extinction coefficient push-pull tricyanofuran-based disperse dyes: Biological activity and dyeing performance

Several push-pull tricyanofuran-based disperse dyes with high molar extinction coefficient were synthesized and fully characterized. The dyes were preparedviaKnoevenagel reaction in dry pyridine under ambient conditions employing acetic acid as catalyst. The condensation process was carried out between the reactive methyl-bearing tricyanofuran moiety and tertiary amine-based arylaldehyde. The molecular structures of the synthesized chromophores were proved by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H and13C NMR) and elemental analysis (C, H, N). The UV-Vis absorbance spectra of the synthesized dyes demonstrated interesting extinction coefficient values, which were found to be influenced by the aromatic-vinyl bridge and the tertiary amine donor group bonded to this aromatic-vinyl bridge moiety. The prepared tricyanofuran-based disperse colorants were dyed on polyester fabrics to afford satisfactory results. The substituents attached to the tertiary amine moiety influenced the absorption maxima. The fastness properties of the dyed polyester samples were measured. The biological activities of the synthesized dyestuffs against fungus (Candida Albican) as well as Gram-positive (S. Aureus) and Gram-negative (E. Coli) pathogens were also evaluated.

ABCG2 INHIBITOR

The present invention relates to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The invention provides an acrylonitrile derivative represented by formula (1): (wherein A represents an optionally substituted 3- to 8-membered heterocyclic ring)

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re