20743-49-1

Basic information

• Product Name: 2-methyl-5-phenyl-2h-tetrazole
• Synonyms: 2H-Tetrazole, 2-methyl-5-phenyl-;2-Methyl-5-phenyltetrazole
• CAS NO: 20743-49-1
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Mol File: 20743-49-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 313.3°Cat760mmHg
• Flash Point: 143.3°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000501mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 2-methyl-5-phenyl-2h-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-phenyl-2h-tetrazole(20743-49-1)
• EPA Substance Registry System: 2-methyl-5-phenyl-2h-tetrazole(20743-49-1)

Safety Data

• Hazardous Substances Data: 20743-49-1(Hazardous Substances Data)

Usage

General Description

2-methyl-5-phenyl-2h-tetrazole is a chemical compound with the molecular formula C8H8N8. It is a tetrazole derivative and is commonly used in pharmaceutical and chemical research. 2-methyl-5-phenyl-2h-tetrazole has been studied for its potential biological and pharmacological activities, and it is known to exhibit antimicrobial and antifungal properties. Additionally, it has been investigated for its potential use as a corrosion inhibitor and as a precursor in the synthesis of various organic compounds. 2-methyl-5-phenyl-2h-tetrazole is a versatile compound with potential applications in various fields such as medicine, chemistry, and materials science.

InChI:InChI=1/C8H8N4/c1-12-10-8(9-11-12)7-5-3-2-4-6-7/h2-6H,1H3

Upstream product

• 119-61-9 benzophenone 
• 131183-01-2 5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole 
• 98-86-2 acetophenone 
• 78-93-3 butanone 
• 78-84-2 isobutyraldehyde 
• 123-72-8 butyraldehyde 
• 14371-10-9 (E)-3-phenylpropenal 
• 135-02-4 ortho-anisaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 89-98-5 2-chloro-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 1571-08-0 methyl 4-formylbenzoate 
• 100-52-7 benzaldehyde 

Downstream Products

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 74-87-3 methylene chloride 
• 7664-41-7 ammonia 
• 74-89-5 methylamine 
• 100-42-5 styrene 
• 4172-91-2 N-((methylimino)methylene)aniline 
• 100-47-0 benzonitrile 
• 69790-73-4 2-Methyl-5-(3-nitrophenyl)-2H-tetrazole 
• 90145-27-0 1-Methyl-3,4-diphenyl-2-pyrazolin-5-carbonsaeure-methylester 
• 90145-28-1 1-Methyl-3,5-diphenyl-2-pyrazolin-4-carbonsaeure-methylester 
• 90145-29-2 1-Methyl-3,4-diphenylpyrazol-5-carbonsaeure-methylester 
• 90145-30-5 1-Methyl-3,5-diphenylpyrazol-4-carbonsaeure-methylester 
• 120819-50-3 C₉H₁₁N₄⁽¹⁺⁾*CH₃O₄S^(1-) 
• 134792-25-9 1-(5-phenyltetrazol-2-yl)butan-2-ol 

Relevant articles and documents

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Alkylation of 5-Substituted 1 H-Tetrazoles via the Diazotization of Aliphatic Amines

A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. This method enables preferential formation of 2,5-disubstituted tetrazoles. A one-pot 1,3-dipolar cycloaddition/diazotization sequence starting from widely available nitriles is also described. Azide residues are quenched in the second step with the nitrite reagent, thus limiting the intrinsic risk associated with trimethylsilyl azide. The reaction conditions were compatible with several functional groups, including thiocyanates, which afford preferentially disubstituted 2-alkyl-5-(substituted-thio)tetrazoles.

Ruthenium-Catalyzed meta-Selective C?H Nitration of Biologically Important Aryltetrazoles

The first example of tetrazole-directed meta-selective C?H nitration is described. This transformation provided a straightforward approach for the synthesis of biologically important m-nitroaryltetrazoles in moderate to excellent yields with good functional group compatibility. In addition, new metallo-β-lactamase inhibitors were obtained by further transformation of the synthesized m-nitroaryltetrazoles. (Figure presented.).

ACLY INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.