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207982-87-4

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207982-87-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 207982-87-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,9,8 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 207982-87:
(8*2)+(7*0)+(6*7)+(5*9)+(4*8)+(3*2)+(2*8)+(1*7)=164
164 % 10 = 4
So 207982-87-4 is a valid CAS Registry Number.

207982-87-4Relevant articles and documents

Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin

Szymanska, Ewa,Kiec-Kononowicz, Katarzyna

, p. 355 - 362 (2002)

Various 5-(chlorobenzylidene)-2-isoniazido and 5-(chlorobenzylidene)-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated in the primary assay for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv. Eight of them exhibited >90% inhibition in the primary screening at 12.5 μg/ml. For these primarily selected compounds the actual MIC and IC50 values were determined. Two of the isoniazid derivatives, for which MIC≤3.13 μg/ml and SI>10, were selected for further screening and investigated for efficacy in vitro in a TB-infected macrophage model. The most promising compound, 5-(3-chlorobenzylidene)-2-(isonicotinoylhydrazino)-imidazoline-4-one, with activity in vitro comparable with rifampin (MIC=0.8 μg/ml, SI>78) was tested in vivo in the animal tuberculosis model but exhibited insignificant activity. For several compounds the primary screening of antimycobacterial activity against Mycobacterium avium (ATCC 25291) was conducted as well, but none of them demonstrated satisfactory activity.

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity

Subtel'Na, Ivanna,Atamanyuk, Dmytro,Szymanska, Ewa,Kiec-Kononowicz, Katarzyna,Zimenkovsky, Borys,Vasylenko, Olexandr,Gzella, Andrzej,Lesyk, Roman

experimental part, p. 5090 - 5102 (2010/09/06)

Series of novel 5-arylidene-2-arylaminothiazol-4(5H)-ones and 2-aryl(benzyl)amino-1H-imidazol-4(5H)-ones were synthesized from appropriate 2-alkylthioazol-4-ones using nucleophilic substitution in position 2 by various anilines and benzylamines and Knoeve

Structure and activity studies of glycine receptor ligands. Part 7. Structural remarks on arylidene-imidazoline-4-one glycinates and glycinamides

Karolak-Wojciechowska, Janina,Kie?-Kononowicz, Katarzyna,Mrozek, Agnieszka

, p. 73 - 81 (2007/10/03)

To improve the physicochemical properties (lipophilicity) of the potential ligands of glycine binding site of NMDA receptor, esters and amides of glycine derivatives of arylidene-imidazolidine-4-ones were obtained. The analysis of their properties (X-ray crystallography, NMR spectral data and theoretical calculations) was performed with respect to the existence of the probable tautomeric forms. Their possible interaction with hypothetical active points of the receptor (taking into the account the model of glycine binding site of NMDA receptor) was discussed on the basis of simulation with IsoStar. program.

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