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Tert-butyl (2-chloropyridin-3-yl)carbamate, also known as Prothioconazole, is a chemical compound that functions as a potent fungicide in agricultural applications. It is characterized by its ability to inhibit the synthesis of ergosterol, a vital component of fungal cell membranes, thereby preventing fungal growth and protecting crops from a variety of diseases.

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  • 209798-48-1 Structure
  • Basic information

    1. Product Name: tert-butyl (2-chloropyridin-3-yl)carbamate
    2. Synonyms: tert-butyl (2-chloropyridin-3-yl)carbamate;(2-Chloro-pyridin-3-yl)-carbaMic acid tert-butyl ester;tert-butyl N-(2-chloropyridin-3-yl)carbamate
    3. CAS NO:209798-48-1
    4. Molecular Formula: C10H13ClN2O2
    5. Molecular Weight: 229
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 209798-48-1.mol
  • Chemical Properties

    1. Melting Point: 84-85 °C(Solv: isopropanol (67-63-0))
    2. Boiling Point: 279.6±25.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.245±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 12.00±0.70(Predicted)
    10. CAS DataBase Reference: tert-butyl (2-chloropyridin-3-yl)carbamate(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-butyl (2-chloropyridin-3-yl)carbamate(209798-48-1)
    12. EPA Substance Registry System: tert-butyl (2-chloropyridin-3-yl)carbamate(209798-48-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 209798-48-1(Hazardous Substances Data)

209798-48-1 Usage

Uses

Used in Crop Protection:
Prothioconazole is used as a fungicide for the purpose of safeguarding crops from fungal infections. Its application helps in controlling a broad spectrum of diseases that affect cereals, oilseed rape, and grapes, ensuring healthier and more productive harvests.
Used in Controlling Specific Pathogens:
In the agricultural industry, Prothioconazole is utilized as a targeted treatment against specific fungal pathogens such as Fusarium, Septoria, and powdery mildew. Its effectiveness against these pathogens is attributed to its mode of action in disrupting ergosterol synthesis, which is crucial for the integrity and function of fungal cell membranes.
Used in Various Application Forms:
Prothioconazole is applied in different forms to suit the needs of various agricultural practices. It is commonly used as a spray or as a seed treatment, providing a convenient and effective means of crop protection.
Used with Safety Precautions:
Given its low mammalian toxicity, Prothioconazole is a preferred choice for crop protection. However, it is essential to handle and apply this chemical according to safety guidelines to minimize potential environmental and health risks, ensuring the sustainable use of this fungicide in agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 209798-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,7,9 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 209798-48:
(8*2)+(7*0)+(6*9)+(5*7)+(4*9)+(3*8)+(2*4)+(1*8)=181
181 % 10 = 1
So 209798-48-1 is a valid CAS Registry Number.

209798-48-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(2-chloropyridin-3-yl)carbamate

1.2 Other means of identification

Product number -
Other names tert-butyl 2-chloropyridin-3-ylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:209798-48-1 SDS

209798-48-1Relevant articles and documents

CDK8/19 INHIBITORS

-

Paragraph 0095, (2021/06/10)

The present invention relates to novel compounds of formula I: which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.

POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

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Page/Page column 335, (2021/06/11)

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Synthetic method of 1, 7-naphthyridine derivative

-

Paragraph 0039-0043; 0048-0052, (2020/03/29)

The invention discloses a synthetic method of a 1, 7-naphthyridine derivative, and relates to the technical field of synthesis of medical intermediates and organic chemical intermediates. The method comprises the following steps of: (1) taking 2-chloro-3-amino-pyridine as a compound I, taking the compound I as a starting raw material, and protecting amino to prepare a compound II; (2) reacting thecompound II with an hydroformylation reagent under an alkaline condition to obtain a compound III; and (3) carrying out cyclization reaction on the compound III and an acrylate compound under the action of Lewis acid to prepare a compound IV. The synthetic method disclosed by the invention is suitable for industrial production, relatively low in cost and simple to operate.

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

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Page/Page column 155, (2020/12/11)

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

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Paragraph 0570; 0571, (2018/04/05)

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

-

Paragraph 0312; 0313, (2018/06/09)

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof.

Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles

Wang, Peng,Farmer, Marcus E.,Huo, Xing,Jain, Pankaj,Shen, Peng-Xiang,Ishoey, Mette,Bradner, James E.,Wisniewski, Steven R.,Eastgate, Martin D.,Yu, Jin-Quan

supporting information, p. 9269 - 9276 (2016/08/05)

Here we report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. The utility for this transformation for drug discovery is showcased by allowing the meta-C-H arylation of a lenalidomide derivative. The first steps toward a silver-free protocol for this reaction are also demonstrated.

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

Demont, Emmanuel H.,Chung, Chun-Wa,Furze, Rebecca C.,Grandi, Paola,Michon, Anne-Marie,Wellaway, Chris,Barrett, Nathalie,Bridges, Angela M.,Craggs, Peter D.,Diallo, Hawa,Dixon, David P.,Douault, Clement,Emmons, Amanda J.,Jones, Emma J.,Karamshi, Bhumika V.,Locke, Kelly,Mitchell, Darren J.,Mouzon, Bernadette H.,Prinjha, Rab K.,Roberts, Andy D.,Sheppard, Robert J.,Watson, Robert J.,Bamborough, Paul

, p. 5649 - 5673 (2015/08/03)

Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependence of

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

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Paragraph 0262, (2015/03/13)

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

Labadie, Sharada,Barrett, Kathy,Blair, Wade S.,Chang, Christine,Deshmukh, Gauri,Eigenbrot, Charles,Gibbons, Paul,Johnson, Adam,Kenny, Jane R.,Kohli, Pawan Bir,Liimatta, Marya,Lupardus, Patrick J.,Shia, Steven,Steffek, Micah,Ubhayakar, Savita,Abbema, Anne Van,Zak, Mark

, p. 5923 - 5930 (2013/10/22)

A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the molecule was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration.

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