21038-66-4

Basic information

• Product Name: PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
• Synonyms: PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE;1H-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIONE ;Pyrido[2,3-d]pyrimidine-2,4-diol;2,8,10-triazabicyclo[4.4.0]deca-2,4,11-triene-7,9-dione;Pyrido[2,3-d]pyrimidine-2,4(1H,3H)
• CAS NO: 21038-66-4
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.13
• Mol File: 21038-66-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 361℃
• Appearance: /
• Density: 1.424
• Refractive Index: 1.593
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.31±0.20(Predicted)
• CAS DataBase Reference: PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(21038-66-4)
• EPA Substance Registry System: PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE(21038-66-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 21038-66-4(Hazardous Substances Data)

Usage

Uses

Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione is used as an inhibitor of mTOR kinase.

InChI:InChI=1/C7H5N3O2/c11-6-4-2-1-3-8-5(4)9-7(12)10-6/h1-3H,(H2,8,9,10,11,12)

Upstream product

• 142169-12-8 C₁₁H₁₀N₆O₄ 
• 590-28-3 potassium cyanate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 57-13-6 urea 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 124-38-9 carbon dioxide 
• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 126728-19-6 N-(2-chloro-3-pyridinecarbonyl)-S-methyl-pseudothiourea 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 126728-17-4 2-Methylsulfanyl-3H-pyrido[2,3-d]pyrimidin-4-one; hydrochloride 
• 13438-65-8 2-aminopyridine-3-carboxamide 
• 541-41-3 chloroformic acid ethyl ester 
• 4663-94-9 pyridine-2,3-dicarboxamide 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 

Downstream Products

• 1260663-38-4 2,4,7-trichloropyrido[3,2-d]pyrimidine 
• 1060816-71-8 2-chloropyrido[2,3-d]pyrimidine 
• 1477917-10-4 pyrido[2,3-d]pyrimidin-2,4-bis(4-phenylbutyl)amine hydroselenite 

Relevant articles and documents

Acetylenic chemistry: Part 15 [1]. Reactions of 1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine with 3-bromoprop-1-yne

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Compounds containing pyrimidine heterocyclic structures and preparation methods and applications thereof

Compounds containing pyrimidine heterocyclic structures and preparation methods and applications thereof, belonging to the field of pharmaceutical technology, the present invention relates to compounds containing pyrimidine heterocyclic structures shown i

Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2

An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE?], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.