212268-44-5Relevant articles and documents
ATROPISOMERISM FOR ENHANCED KINASE INHIBITOR SELECTIVITY
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, (2019/01/10)
The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly inter
Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors
Smith, Davis E.,Marquez, Isaac,Lokensgard, Melissa E.,Rheingold, Arnold L.,Hecht, David A.,Gustafson, Jeffrey L.
, p. 11754 - 11759 (2015/10/05)
Many biologically active molecules exist as rapidly interconverting atropisomeric mixtures. Whereas one atropisomer inhibits the desired target, the other can lead to off-target effects. Herein, we study atropisomerism as a possibility to improve the sele
PYRROLOPYRIMIDINE DERIVATIVES
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Page 60, (2010/02/07)
The invention relates to compounds of the formula 1or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.