2134-76-1

Basic information

• Product Name: 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid
• Synonyms: 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid;7,8-Dihydropteroic acid;dihydropteroate
• CAS NO: 2134-76-1
• Molecular Formula: C₁₄H₁₄N₆O₃
• Molecular Weight: 314.3
• Mol File: 2134-76-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 597.3°Cat760mmHg
• Flash Point: 315°C
• Appearance: /
• Density: 1.7g/cm³
• Vapor Pressure: 4.09E-15mmHg at 25°C
• Refractive Index: 1.803
• CAS DataBase Reference: 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid(2134-76-1)
• EPA Substance Registry System: 4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoic acid(2134-76-1)

Safety Data

• Hazardous Substances Data: 2134-76-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A pteroic acid derivative arising from formal hydrogenation of the 7,8-double bond of pteroic acid.

InChI:InChI=1/C14H14N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,16H,5-6H2,(H,22,23)(H4,15,17,19,20,21)

Upstream product

• 119-24-4 pteroic acid 
• 3545-84-4 6-hydroxymethyl-7,8-dihydro-pterin pyrophosphate 
• 150-13-0 4-amino-benzoic acid 
• 86-01-1 Guanosine 5'-triphosphate 
• 77773-79-6 N-(1-Amino-2,2-dimethoxypropyl)-p-aminobenzoic acid 
• 77773-80-9 1-<(2-Amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-2,2-dimethoxy-3-<(p-carboxyphenyl)amino>propane 
• 77773-77-4 4-[(3-Azido-2,2-dimethoxy-propyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid ethyl ester 
• 77773-78-5 N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid 

Downstream Products

• 119-24-4 pteroic acid 
• 15574-38-6 dihydrofolic acid 
• 119-24-4 Pteroic acid 

Relevant articles and documents

Synthesis and analysis of bacterial folate metabolism intermediates and antifolates

The mechanism of action of para-aminosalicylic acid (PAS), a drug used to treat drug-resistant tuberculosis (TB), has been confirmed through the first synthesis and biochemical characterization of its active metabolite 7. The synthesis features the coupling of N2-acetyl-6-formylpterin obtained from the degradation of folic acid and appropriately functionalized arylamines to form Schiff bases. The sequential chemoselective reduction of the imine and pterin ring led to the formation of dihydrofolate analogue 7 and two other dihydropteroate species.

Folate analogues. XVII. Synthesis of pteroic acid and 4-amino-4-deoxypteroic acid

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