214630-00-9

Basic information

• Product Name: BOC-7-HYDROXY-D-TIC-OH
• Synonyms: (3R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;Boc-D-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline;(R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(R)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid;2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-7-hydroxy-, 2-(1,1-dimethylethyl) ester, (3R)-;2,3(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-7-hydroxy, 2-(1,1-dimentylethyl) ester, (3R);(R)-7-Hydroxy-2-Boc-3,4-dihydro-isoquinoline-3-carboxylic acid;Boc-(3R)-1,2,3,4-tetrahydroisoquinoline-7-hydroxy-3-carboxylic acid≥ 99% (HPLC)
• CAS NO: 214630-00-9
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol File: 214630-00-9.mol

Chemical Properties

• Boiling Point: 484.716 °C at 760 mmHg
• Flash Point: 246.948 °C
• Appearance: /
• Density: 1.274g/cm³
• Refractive Index: 1.561
• Storage Temp.: -15°C
• PKA: 2.91±0.20(Predicted)
• CAS DataBase Reference: BOC-7-HYDROXY-D-TIC-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-7-HYDROXY-D-TIC-OH(214630-00-9)
• EPA Substance Registry System: BOC-7-HYDROXY-D-TIC-OH(214630-00-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 214630-00-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BOC-7-HYDROXY-D-TIC-OH is used as an intermediate compound for the synthesis of highly potent and selective opioid κ receptor antagonists. These antagonists play a significant role in the treatment of various medical conditions, including pain management and addiction therapy, by blocking the effects of opioids on the κ receptors in the brain.

InChI:InChI=1/C15H19NO5/c1-15(2,3)21-14(20)12-10-7-9(17)5-4-8(10)6-11(16-12)13(18)19/h4-5,7,11-12,16-17H,6H2,1-3H3,(H,18,19)/t11?,12-/m1/s1

Downstream Products

• 1016162-90-5 tert-butyl (3R)-3-{[(1S)-1-{[(3R,4R)-4-(3-carbamoylphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-2-methylpropyl]carbamoyl}-7-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1016316-94-1 (3R)-7-hydroxy-N-[(1S,2S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-2-methylbutyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 785835-79-2 (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide 
• 441003-76-5 tert-butyl-(3R)-7-hydroxy-3-{[((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)amino]carbonyl}-3,4-dihydrohydro-2(1H)-isoquinolinecarboxylate