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214697-26-4

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  • 4-AMINO-5-(3-BROMOPHENYL)-7-(6-MORPHOLINO-PYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE DIHYDROCHLORIDE

    Cas No: 214697-26-4

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  • Pyrido[2,3-d]pyrimidin-4-amine,5-(3-bromophenyl)-7-[6-(4-morpholinyl)-3-pyridinyl]-

    Cas No: 214697-26-4

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214697-26-4 Usage

Uses

ABT 702 Dihydrochloride is employed in the assay for quantitative high-?throughput screening of anti-?hepatitis C virus compounds.

Biological Activity

Potent non-nucleoside adenosine kinase inhibitor (IC 50 = 1.7 nM), selective over other sites of adenosine interaction (A 1 , A 2A and A 3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 214697-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,6,9 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214697-26:
(8*2)+(7*1)+(6*4)+(5*6)+(4*9)+(3*7)+(2*2)+(1*6)=144
144 % 10 = 4
So 214697-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H19BrN6O.2ClH/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29;;/h1-5,10-13H,6-9H2,(H2,24,26,27,28);2*1H

214697-26-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name ABT 702 dihydrochloride,5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-aminedihydrochloride

1.2 Other means of identification

Product number -
Other names ABT-702 dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:214697-26-4 SDS

214697-26-4Downstream Products

214697-26-4Relevant articles and documents

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors

Matulenko, Mark A.,Lee, Chih-Hung,Jiang, Meiqun,Frey, Robin R.,Cowart, Marlon D.,Bayburt, Erol K.,DiDomenico Jr., Stanley,Gfesser, Gregory A.,Gomtsyan, Arthur,Guo, Zhu Zheng,McKie, Jeffery A.,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,Alexander, Karen M.,McGaraughty, Steve,Wismer, Carol T.,Mikusa, Joseph,Marsh, Kennan C.,Snyder, Ronald D.,Diehl, Marilyn S.,Kowaluk, Elizabeth A.,Jarvis, Michael F.,Bhagwat, Shripad S.

, p. 3705 - 3720 (2007/10/03)

4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. We discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).

Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors

Cowart, Marlon,Lee, Chih-Hung,Gfesser, Gregory A.,Bayburt, Erol K.,Bhagwat, Shripad S.,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,McGaraughty, Steve,Wismer, Carol T.,Mikusa, Joseph,Zhu, Chang,Alexander, Karen M.,Jarvis, Michael F.,Kowaluk, Elizabeth A.

, p. 83 - 86 (2007/10/03)

The synthesis and SAR of a novel series of non-nucleoside pyridopyrimidine inhibitors of the enzyme adenosine kinase (AK) are described. It was found that pyridopyrimidines with a broad range of medium and large non-polar substituents at the 5-position potently inhibited AK activity. A narrower range of analogues was capable of potently inhibiting adenosine phosphorylation in intact cells indicating an enhanced ability of these analogues to penetrate cell membranes. Potent AK inhibitors were found to effectively reduce nociception in animal models of thermal hyperalgesia and persistent pain. (C) 2000 Elsevier Science Ltd.

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