21564-73-8

Basic information

• Product Name: 6,7-Dimethyl-1,4-dihydronaphthalene
• CAS NO: 21564-73-8
• Molecular Weight: 158.243
• Mol File: 21564-73-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,7-Dimethyl-1,4-dihydronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethyl-1,4-dihydronaphthalene(21564-73-8)
• EPA Substance Registry System: 6,7-Dimethyl-1,4-dihydronaphthalene(21564-73-8)

Safety Data

• Hazardous Substances Data: 21564-73-8(Hazardous Substances Data)

Upstream product

• 581-40-8 2,3-dimethylnaphthalene 

Relevant articles and documents

Substituted 1,2,3,4-Tetrahydroaminonaphthols: Antihypertensive Agents, Calcium Channel Blockers, and Adrenergic Receptor Blockers with Catecholamine-Depleting Effects

Substituted 1,2,3,4-tetrahydroaminonaphthols were found to be calcium channel blockers with antihypertensive properties.These compounds also possessed adrenergic β-receptor blocking activity.From the structure-activity studies, no clear correlation emerged between the in vitro calcium channel blocking activity and the acute antihypertensive activity in cannulated spontaneously hypertensive rats.Extensive pharmacological testing of selected compounds indicated that aminonaphthols are antihypertensive agents with many pharmacological properties.The relative contribution of various pharmacological actions toward the observed antihypertensive activity is unclear.Since the clinically useful calcium channel blocker verapamil is structurally related to these compounds, one of the aminonaphthols, trans-3--1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphthalenol (12), was compared with verapamil for calcium channel blocking activity, adrenergic blocking activity, and catecholamine-depleting activity.Both compopunds were found to be equipotent in these test systems.