216159-03-4

Basic information

• Product Name: 4-Bromo-2-fluorobenzenesulfonyl chloride
• Synonyms: 2-FLUORO-4-BROMOBENZENESULFONYL CHLORIDE;4-BROMO-2-FLUOROBENZENESULFONYL CHLORIDE;4-BROMO-2-FLUOROBENZENESULPHONYL CHLORIDE;BUTTPARK 147\11-41;4-Bromo-2-fluorobenzenesulphonyl chloride 99%;4-Bromo-2-fluorobenzenesulphonylchloride99%;4-broMo-2-fluorobenzene-1-sulfonyl chloride;4-BroMo-2-fluorobenzenesulfonyl chloride 97%
• CAS NO: 216159-03-4
• Molecular Formula: C6H3BrClFO2S
• Molecular Weight: 273.51
• Product Categories: Fluorobenzene;Aromatic Halides (substituted);Benzenesulfonyl chloride;Benzenes;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Fluorine series
• Mol File: 216159-03-4.mol

Chemical Properties

• Melting Point: 63-66 °C(lit.)
• Boiling Point: 84°C 0,5mm
• Flash Point: 84°C/0.5mm
• Appearance: /
• Density: 1.867 g/cm³
• Vapor Pressure: 2.04mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Toluene
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-Bromo-2-fluorobenzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-fluorobenzenesulfonyl chloride(216159-03-4)
• EPA Substance Registry System: 4-Bromo-2-fluorobenzenesulfonyl chloride(216159-03-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 22-26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 216159-03-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
4-Bromo-2-fluorobenzenesulfonyl chloride is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in the Synthesis of (E)-4-bromo-2-fluoro-1-styrylbenzene:
In the field of organic chemistry, 4-Bromo-2-fluorobenzenesulfonyl chloride is utilized as a key reactant in the synthesis of (E)-4-bromo-2-fluoro-1-styrylbenzene. This specific compound has potential applications in various industries, such as the development of new materials with unique properties or the creation of novel pharmaceutical agents.
Used in the Generation of Tricyclic Benzothiadiazepine-1,1-dioxide:
4-Bromo-2-fluorobenzenesulfonyl chloride also plays a crucial role in the formation of tricyclic benzothiadiazepine-1,1-dioxide through pairing reactions with (S)-prolinol. This complex molecule has potential applications in medicinal chemistry, particularly in the development of new drugs with improved therapeutic profiles.

InChI:InChI=1/C7H3ClF4/c8-2-3-1-4(9)6(11)7(12)5(3)10/h1H,2H2

Upstream product

• 367-24-8 4-bromo-2-fluoroaniline 

Downstream Products

• 1447083-96-6 C₂₀H₁₅BrFNO₅S 
• 1447084-88-9 C₂₀H₁₅BrFNO₅S 
• 1355680-54-4 4-bromo-N-(tert-butyl)-2-fluorobenzenesulfonamide 
• 1442431-72-2 4-bromo-N-(tert-butyl)-2-(neopentyloxy)benzenesulfonamide 
• 1443103-47-6 N,N-dibenzyl-4-bromo-2-fluorobenzenesulfonamide 
• 1215011-46-3 2-fluoro-4-(2-piperazin-1-yl-pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide 
• 1365719-80-7 N-(3-(1H-tetrazol-5-yl)phenyl)-4-bromo-2-fluorobenzenesulfonamide 
• 1581710-44-2 4-bromo-N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-2-fluorobenzenesulfonamide 
• 1055995-87-3 4-bromo-N,N-diethyl-2-fluorobenzenesulfonamide 

Relevant articles and documents

NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR?, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.