216690-18-5Relevant articles and documents
Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis
?tv?s, Sándor B.,Pericàs, Miquel A.,Kappe, C. Oliver
, p. 11141 - 11146 (2019)
The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (-)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The critical step is a solvent-free organocatalytic conjugate addition followed
Enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in water
Ma, Anqi,Zhu, Shaolin,Ma, Dawei
, p. 3075 - 3077 (2008/09/20)
The Michael addition of malonates to α,β-unsaturated aldehydes catalyzed by O-TMS protected diphenylprolinols and acetic acid in water occurs at 0 °C to rt. In most cases, the reaction runs to completion in less than 24 h. A wide range of aldehydes includ
