21771-88-0Relevant articles and documents
An Alternative and efficient route to chlorophacinone
Csuk, Rene,Barthel, Alexander,Stroehl, Dieter
, p. 95 - 97 (2011)
A straightforward synthesis for the anticoagulant rodenticide chlorophacinone is described. The short synthesis uses commercially available mandelic acid and 1,3-indanedione as staring materials.
Ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2
Yan, Si-Shun,Zhu, Lei,Ye, Jian-Heng,Zhang, Zhen,Huang, He,Zeng, Huiying,Li, Chao-Jun,Lan, Yu,Yu, Da-Gang
, p. 4873 - 4878 (2018/06/07)
The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine. Computational studies reveal that this umpolung reaction proceeds through the generation of a Ru-nitrenoid followed by concerted [4 + 2] cycloaddition with CO2.
Diastereoselectivity in the reduction of sterically unbiased 2,2-diarylcyclopentanones
Halterman, Ronald L.,McEvoy, Marjorie A.
, p. 6690 - 6695 (2007/10/02)
Reduction of sterically unbiased 2-phenyl-2-(4-X-phenyl)cyclopentanones 1 (X = NO2, Br, Cl, OCH3, OH, NH2) with either sodium borohydride in methanol or lithium borohydride in tetrahydrofuran at 0°C produced diastereomeric