21972-99-6

Basic information

• Product Name: 1H-Pyrrole-1-carboxylic acid
• Synonyms: N-carboxypyrrole;1-carboxypyrrole;1H-Pyrrole-1-carboxylic acid;pyrrole carboxylic acid;1-Pyrrolcarbonsaeure;N-pyrrolcarboxylic acid
• CAS NO: 21972-99-6
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• Mol File: 21972-99-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-carboxylic acid(21972-99-6)
• EPA Substance Registry System: 1H-Pyrrole-1-carboxylic acid(21972-99-6)

Safety Data

• Hazardous Substances Data: 21972-99-6(Hazardous Substances Data)

Usage

Aromatic ring

Five-membered with one nitrogen atom

Functional group

Carboxylic acid (carboxyl group)

Contains

Carbonyl and hydroxyl groups bonded to the same carbon atom

Used in

Organic synthesis and pharmaceutical research

Medicinal properties

Anti-inflammatory and anti-tumor activities

Precursor to

Various pharmaceutical drugs and agrochemicals

Hazards

Harmful if ingested, inhaled, or absorbed through the skin, and may cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 109-97-7 pyrrole 
• 124-38-9 carbon dioxide 

Downstream Products

• 3042-22-6 2-phenyl-1H-pyrrole 
• 6308-45-8 pyrrole carboxamide 
• 446883-22-3 4-tert-Butoxycarbonylamino-1-cyclopropylmethyl-1H-pyrrole-2-carboxylic Acid Pentafluorophenyl Ester 
• 1061574-01-3 C₂₉H₃₂Cl₆N₆O₅SSi 
• 1254691-05-8 C₂H₄O₂*C₂₇H₃₃Cl₃N₆O₄SSi 
• 1061574-19-3 C₃₀H₃₇Cl₃N₄O₅S₂Si 
• 1061574-16-0 C₂₈H₃₃Cl₃N₄O₅S₂Si 
• 1061573-99-6 C₂₇H₃₃N₃O₂Si 
• 1061574-13-7 C₂₅H₃₀N₂O₄Si 
• 1254691-11-6 C₂₁H₂₁Cl₆N₇O₁₀S 
• 1061574-09-1 C₂₁H₂₁Cl₆N₇O₉S 
• 1061574-23-9 C₂₉H₃₂Cl₆N₆O₅SSi 
• 1264291-81-7 N-(2-(2,2-dibromovinyl)-4,5-dimethoxy-phenyl)-1H-pyrrole-1-carboxamide 
• 1264291-80-6 N-(2-(2,2-dibromovinyl)phenyl)-1H-pyrrole-1-carboxamide 

Relevant articles and documents

The pyrrolecarboxylic acid production

PROBLEM TO BE SOLVED: To provide a novel production method of pyrrole carboxylic acids, with which carbon dioxide can be utilized as a carbon source and a pyrrole carboxylic acid useful as a production raw material of medicines and agrochemicals is easily produced by making 1H-pyrrole react with carbon dioxide so that a carboxy group is directly introduced into a pyrrole skeleton in a low pressure of 1 MPa or less.SOLUTION: In introducing a carboxy group into a pyrrole skeleton by directly carboxylating 1H-pyrrole with carbon dioxide in a reaction solvent and in the presence of a catalyst, an excess of basic catalyst over 1H-pyrrole is used as the catalyst so that a pyrrole carboxylic acid is produced by introducing a carboxy group into a pyrrole skeleton in a low pressure of 1 MPa or less. The basic catalyst is lithium t-butoxide.