21981-37-3

Basic information

• Product Name: Di-tert-butylamine
• Synonyms: 1,1'-Iminobis(1,1-dimethylethane);Bis(tert-butyl)amine;Di-tert-butylamine;N-(1,1-Dimethylethyl)-2-methyl-2-propanamine;2-PropanaMine, N-(1,1-diMethylethyl)-2-Methyl-;N-tert-butyl-2-Methylpropan-2-aMine
• CAS NO: 21981-37-3
• Molecular Formula: C₈H₁₉N
• Molecular Weight: 129.24
• Mol File: 21981-37-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 129.4°C at 760 mmHg
• Flash Point: 12.8°C
• Appearance: /
• Density: 0.762g/cm³
• Vapor Pressure: 10.2mmHg at 25°C
• Refractive Index: 1.417
• PKA: 10.76±0.48(Predicted)
• CAS DataBase Reference: Di-tert-butylamine(CAS DataBase Reference)
• NIST Chemistry Reference: Di-tert-butylamine(21981-37-3)
• EPA Substance Registry System: Di-tert-butylamine(21981-37-3)

Safety Data

• Hazardous Substances Data: 21981-37-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 491, 1984 DOI: 10.1016/S0040-4039(00)99919-2

InChI:InChI=1/C8H19N/c1-7(2,3)9-8(4,5)6/h9H,1-6H3

Upstream product

• 109-95-5 ethyl nitrite 
• 677-22-5 tert-butylmagnesium chloride 
• 507-19-7 t-butyl bromide 
• 67-56-1 methanol 
• 82881-21-8 1,3-Di-tert-butyl-2-(di-tert-butylamino)-4,4-dimethyl-1,3,2,4-diazaphosphasiletidin 

Downstream Products

• 110808-07-6 1-(2-Allyl-5-methyl-phenoxy)-3-(di-tert-butyl-amino)-propan-2-ol 
• 20265-77-4 di-tertbutylaniline 
• 110808-09-8 1-(2-Allyl-4-methyl-phenoxy)-3-(di-tert-butyl-amino)-propan-2-ol 
• 63819-70-5 N-Nitroso-di-tert.-butylamin 

Relevant articles and documents

An improved and one-pot procedure to the synthesis of symmetric amines by domino reactions of 5-methyl-1,3,4-thiadiazole-2-amine, a new nitrogen atom donor, and alkyl halides

Abstract: A new one-pot method has been introduced in this work for the synthesis of symmetrical primary, secondary, and tertiary alkyl amines from alkyl halides and 5-methyl-1,3,4-thiadiazole-2-amine as a nitrogen-transfer reagent. In this method, all three types of amines have been successfully prepared after changing the ratio of substrates and base control. In addition to the introduction of a new nitrogen-transfer reagent, other important features of this work include normal atmospheric conditions and excellent yields under mild reaction conditions.