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CAS

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220445-20-5

4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)phenylamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 220445-20-5 Structure

  • Basic information

    1. Product Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)phenylamine
    2. Synonyms: GYKI-47261
    3. CAS NO:220445-20-5
    4. Molecular Formula: C18H15ClN4
    5. Molecular Weight: 395.7134
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 220445-20-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)phenylamine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)phenylamine(220445-20-5)
    11. EPA Substance Registry System: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)phenylamine(220445-20-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220445-20-5(Hazardous Substances Data)

220445-20-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 220445-20-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,4,4 and 5 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 220445-20:
(8*2)+(7*2)+(6*0)+(5*4)+(4*4)+(3*5)+(2*2)+(1*0)=85
85 % 10 = 5
So 220445-20-5 is a valid CAS Registry Number.

220445-20-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(4-Aminophenyl)-8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]-benzodiazepine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220445-20-5 SDS

220445-20-5Downstream Products

220445-20-5Relevant articles and documents

New non competitive AMPA antagonists

Abraham, Gizella,Solyom, Sandor,Csuzdi, Emese,Berzsenyi, Pal,Ling, Istvan,Tarnawa, Istvan,Hamori, Tamas,Pallagi, Istvan,Horvath, Katalin,Andrasi, Ferenc,Kapus, Gabor,Harsing Jr., Laszlo G.,Kiraly, Istvan,Patthy, Miklos,Horvath, Gyula

, p. 2127 - 2143 (2007/10/03)

New halogen atom substituted 2,3-benzodiazepine derivatives condensed with an azole ring on the seven membered part of the ring system of type 3 and 4 as well as 5 and 6 were synthesized. It was found that chloro-, dichloro- and bromo-substitutions in the benzene ring and additionally imidazole ring condensation on the diazepine ring can successfully substitute the methylenedioxy group in the well known molecules GYKI 52466 (1) and GYKI 53773 (2) and the 3-acetyl-4-methyl structural feature in 2, respectively, preserving the highly active AMPA antagonist characteristic of the original molecules. From the most active compounds (3b,i) 3b (GYKI 47261) was chosen for detailed investigations. 3b revealed an excellent, broad spectrum anticonvulsant activity against seizures evoked by electroshock and different chemoconvulsive agents indicating a possible antiepileptic efficacy. 3b was found to be highly active in a transient model of focal ischemia predictive of a therapeutic value in human stroke. 3b also reversed the dopamine depleting effect of MPTP and antagonized the oxotremorine induced tremor in mice indicating a potential antiparkinson activity. Copyright (C) 2000 Elsevier Science Ltd.

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