220728-62-1

Basic information

• Product Name: 4-IODO-2-METHOXYTOLUENE
• Synonyms: 4-Iodo-2-methoxy-1-methyl-benzene
• CAS NO: 220728-62-1
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.0609
• Product Categories: Aromatic Halides (substituted)
• Mol File: 220728-62-1.mol

Chemical Properties

• Boiling Point: 255.2 °C at 760 mmHg
• Flash Point: 108.2 °C
• Appearance: /
• Density: 1.634 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-IODO-2-METHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-METHOXYTOLUENE(220728-62-1)
• EPA Substance Registry System: 4-IODO-2-METHOXYTOLUENE(220728-62-1)

Safety Data

• Hazardous Substances Data: 220728-62-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-IODO-2-METHOXYTOLUENE is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new medications due to its unique iodine substitution and reactivity in chemical reactions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-IODO-2-METHOXYTOLUENE serves as a building block in the synthesis of agrochemicals, playing a crucial role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
4-IODO-2-METHOXYTOLUENE is utilized as a versatile building block in organic synthesis, enabling the construction of a wide range of organic compounds for various applications, including specialty chemicals and materials.

Upstream product

• 16452-01-0 ortho-cresidine 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 220728-63-2 2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine 
• 1122012-31-0 5-(3-methoxy-4-methylphenyl)pentanal 
• 220728-68-7 2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene 
• 220728-76-7 Acetic acid (S)-3-methoxymethoxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-49-4 (S)-2-methoxy-1-methyl-4-(1-(phenylsulfonyl)propan-2-yl)benzene 
• 220728-57-4 Acetic acid (S)-3-hydroxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-73-4 Acetic acid (R)-3-hydroxy-2-(3-methoxy-4-methyl-phenyl)-propyl ester 
• 220728-66-5 (R)-3-Methoxymethoxy-2-(3-methoxy-4-methyl-phenyl)-propan-1-ol 
• 220728-77-8 2-Methoxy-1-methyl-4-((S)-1-methyl-2-phenylsulfanyl-ethyl)-benzene 
• 220728-59-6 2-(3-methoxy-4-methyl-phenyl)-propane-1,3-diol 
• 220728-54-1 (S)-2-(3-methoxy-4-methylphenyl)propan-1-ol 
• 30199-27-0 (R)-2-methoxy-1-methyl-4-(6-methylhept-5-en-2-yl)benzene 
• 59684-62-7 (R)-(-)-xanthorrhizol 

Relevant articles and documents

Synthesis of complex ortho-allyliodoarenes by employing the reductive iodonio-claisen rearrangement

The reductive iodonio-Claisen rearrangement (RICR), involving complex aromatic λ3-iodanes and allyltrimethylsilane, was investigated. The RICR reaction of complex substituted aromatic hypervalent iodine (III) compounds and an allylmetal partner was conducted. The anionic oxy Cope rearrangement was found to be approximately 1010 to 1017 times faster than the neutral oxy Cope rearrangement due to weakening of the adjacent C-C bond by the oxygen anion. The results also indicate that the steric and electronic nature of the aromatic λ3-iodanes is the dominant factor influencing the [3,3]-sigmatropic rearrangement reaction. The removal of tert-butyl ether protecting group by using trifluroacetic acid in dichloromethane in the presence of triisopropylsilane gives the natural product broussin in 39% yield.

PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS

PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.