22118-00-9

Basic information

• Product Name: 2,3,4,5,6,7-Hexahydro-1H-indene-1-one
• Synonyms: 2,3,4,5,6,7-Hexahydro-1H-indene-1-one;4,5,6,7-Tetrahydro-1-indanone
• CAS NO: 22118-00-9
• Molecular Formula: C₉H₁₂O
• Molecular Weight: 136.19
• Mol File: 22118-00-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3,4,5,6,7-Hexahydro-1H-indene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5,6,7-Hexahydro-1H-indene-1-one(22118-00-9)
• EPA Substance Registry System: 2,3,4,5,6,7-Hexahydro-1H-indene-1-one(22118-00-9)

Safety Data

• Hazardous Substances Data: 22118-00-9(Hazardous Substances Data)

Usage

Uses

Used in Fragrance Industry:
2,3,4,5,6,7-Hexahydro-1H-indene-1-one is used as a fragrance ingredient for its sweet, floral, and spicy scent. It is incorporated into a variety of cosmetic and personal care products such as perfumes, lotions, and soaps to enhance their aroma.
Used as a Fixative:
In the fragrance industry, 2,3,4,5,6,7-Hexahydro-1H-indene-1-one is used as a fixative to help prolong the scent of products, ensuring that the fragrance lasts longer on the user.
Used in Organic Synthesis:
2,3,4,5,6,7-Hexahydro-1H-indene-1-one has potential applications in the synthesis of organic compounds, contributing to the development of new chemical products.
Used in Pharmaceutical Industry:
This chemical also has potential uses in the pharmaceutical industry, where it may be utilized in the synthesis of various pharmaceuticals.
However, it is important to handle 2,3,4,5,6,7-Hexahydro-1H-indene-1-one with care, as it can be an irritant to the skin, eyes, and respiratory system.

Upstream product

• 636-82-8 cyclohexene-1-carboxylic acid 

Downstream Products

• 16783-22-5 cis-octahydro-1H-inden-1-one 
• 105543-59-7 2,3,4,5,6,7-hexahydro-1H-inden-1-one cyclic (1S,2S)-1,2-bis<(benzyloxy)methyl>ethylene acetal 
• 29927-85-3 hexahydro-indan-1-one 
• 105543-60-0 (3aS,7aR)-2,3,4,5,6,7-hexahydro-3a,7a-methano-1H-inden-1-one cyclic (1S,2S)-bis-<(benzyloxy)methyl>ethylene acetal 
• 105543-60-0 C₂₈H₃₄O₄ 
• 89244-93-9 2,4-dinitrophenylhydrazone of 2,3,4,5,6,7-hexahydro-1H-inden-1-one 
• 4430-31-3 (+/-)-(4aR,8aR)-octahydro-2H-chromen-2-one 
• 499158-35-9 8-phenylselanyl-9,10-bis-[(triisopropylsilanyl)-methyl]-tricyclo[4.2.2.0^1,6]dec-9-ene-7-carboxylic acid dimethylamide 
• 499158-31-5 8-phenylselanyl-9,10-bis-trimethylsilanylmethyl-tricyclo[4.2.2.0^1,6]dec-9-ene-7-carboxylic acid methyl ester 
• 2826-65-5 (+/-)-cis-Hexahydro-indan-1-on 

Relevant articles and documents

Regio- and stereoselective rearrangement reactions of various α,β- epoxy acylates: Suitable combination of acyl groups and Lewis acids

Regio- and stereoselective rearrangement reactions of various α,β- epoxy acylates including acyclic, monocyclic and bicyclic systems occurred under a suitable combination of acyl groups (benzoyl, p-nitrobenzoyl, camphanoyl) and Lewis acids (BF3

Synthesis of Cyclopentenones through Rhodium-Catalyzed C-H Annulation of Acrylic Acids with Formaldehyde and Malonates

An efficient rhodium-catalyzed protocol for the synthesis of cyclopentenones based on a three-component reaction of acrylic acids, formaldehyde, and malonates via vinylic C-H activation is reported. Exploratory studies showed that 5-alkylation of as-prepared cyclopentenones could be realized smoothly by the treatment of a variety of alkyl halides with a Na2CO3/MeOH solution. Excess formaldehyde and malonate led to a multicomponent reaction that afforded the multisubstituted cyclopentenones through a Michael addition.

Acid-promoted rearrangement of α,β-epoxy acylates: Remarkable effects of an acyl group and a Lewis acid

Remarkable steric and electrostatic effects of acyl groups and exceptionally bulky Lewis acid, (MABR), which make the rearrangement reaction applicable to various types of reaction systems including acyclic ones in the acid-promoted rearrangement of α,β-epoxy acylates, were found.

Acid-promoted rearrangement of cyclic α,β-epoxy acylates: Stereoselective synthesis of spirocyclanes and quaternary carbon centers

The rearrangement reaction of α,β-epoxy acylates in cyclic systems was studied. The treatment of cis-derivatives with a Lewis acid afforded rearranged products via the regioselective β-cleavage of the oxirane ring due to the electron-withdrawing nature of the acyloxy group, whereas trans- derivatives enhanced the neighboring group participation to yield only a small amount of rearranged products. This rearrangement reaction proved to be useful for the construction of a variety of spirocyclane systems or quaternary carbon centers on rings and could be applied to their syntheses as optically active forms.