221198-34-1

Basic information

• Product Name: 1-(2-fluoro-4-nitro-phenyl)-azetidine
• Synonyms: 1-(2-fluoro-4-nitro-phenyl)-azetidine
• CAS NO: 221198-34-1
• Molecular Weight: 196.181
• Mol File: 221198-34-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-4-nitro-phenyl)-azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-4-nitro-phenyl)-azetidine(221198-34-1)
• EPA Substance Registry System: 1-(2-fluoro-4-nitro-phenyl)-azetidine(221198-34-1)

Safety Data

• Hazardous Substances Data: 221198-34-1(Hazardous Substances Data)

Upstream product

• 503-29-7 azetidine 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 221199-02-6 4-azetidin-1-yl-3-fluorophenylamine 

Relevant articles and documents

Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2.1) Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl oxazolidinones

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calculated log P value and the balance between 5-hydrophilic (or hydrophobic) substituent and hydrophobic (or hydrophilic) substituents on the benzene ring. Some of 5-thiocarbonyl oxazolidinones were found to have good in vitro antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).