22144-60-1Relevant articles and documents
Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity
Du, Tian,Wang, Biwen,Wang, Chao,Xiao, Jianliang,Tang, Weijun
supporting information, p. 1241 - 1244 (2020/10/02)
A chiral cobalt pincer complex, when combined with an achiral electron-rich mono-phosphine ligand, catalyzes efficient asymmetric hydrogenation of a wide range of aryl ketones, affording chiral alcohols with high yields and moderate to excellent enantioselectivities (29 examples, up to 93% ee). Notably, the achiral mono-phosphine ligand shows a remarkable effect on the enantioselectivity of the reaction.
Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands
Wang, Mengna,Zhang, Ling,Sun, Hao,Chen, Qian,Jiang, Jian,Li, Linlin,Zhang, Lin,Li, Li,Li, Chun
, (2021/03/24)
The Ru-catalyzed asymmetric hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcohols in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asymmetric hydrogenation was proposed and verified by NMR spectroscopy.
Method for asymmetric functionalization of nickel-hydrogen catalytic olefin migration promoted by ligand relay strategy
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Paragraph 0089-0091, (2021/06/12)
The invention discloses a method for asymmetric functionalization of nickel-hydrogen catalytic olefin migration promoted by a ligand relay strategy. Under the action of a metal nickel salt, an achiral ligand, a chiral ligand, alkali, a hydrogen source, an additive and the like, olefin and various electrophilic reagents are dissolved in an organic solvent for reaction, and the chiral compound with excellent regioselectivity and enantioselectivity is obtained. According to the method, the chiral compound containing various functional groups can be efficiently synthesized, the product has high enantioselectivity, the raw materials are simple and easy to obtain, and operation is easy and convenient.