2217-08-5 Usage
General Description
5,5-DI-N-PROPYLBARBITURIC ACID, also known as dipropylbarbituric acid, is a barbiturate drug that belongs to the class of sedative-hypnotic agents. It acts on the central nervous system to produce sedative and hypnotic effects, making it useful in treating insomnia and as a pre-anesthetic. It works by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to a calming effect on the body. However, it also carries a risk of dependence and tolerance with prolonged use, and may have potential for abuse. Its use is now limited due to the availability of safer and more effective alternatives, but it remains an important compound in the study of barbiturate pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 2217-08-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,1 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2217-08:
(6*2)+(5*2)+(4*1)+(3*7)+(2*0)+(1*8)=55
55 % 10 = 5
So 2217-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-6H2,1-2H3,(H2,11,12,13,14,15)
2217-08-5Relevant articles and documents
Substituent effects on partition coefficients of barbituric acids
Wong,McKeown
, p. 926 - 932 (2007/10/02)
Precise partition coefficients in 1-octanol-water at 25°C were determined for three 2-thiobarbituric acids and 14 barbituric acids with a wider range of substituents. The experimental log P values (log P(exp)) of barbituric acids were correlated with the carbon number and the branching effect of the C5 substituent(s) by linear regression analysis. The carbon number term makes a major contribution to the partition coefficients. The contribution of the polar effect of the C5 substituents was insignificant in contrast to a previous report. Hydrophobic constants (π) were determined for allyl, phenyl, and chloro-substituents, and these emperical π values gave much closer predicted calculated log P (log P(calc)) values when applied to the reported log P(exp) values.