22202-46-6

Basic information

• Product Name: (Z)-(S)-3-(trityloxy)propane-1,2-diyl dioleate
• Synonyms: (Z)-(S)-3-(trityloxy)propane-1,2-diyl dioleate
• CAS NO: 22202-46-6
• Molecular Weight: 863.318
• Mol File: 22202-46-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-(S)-3-(trityloxy)propane-1,2-diyl dioleate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(S)-3-(trityloxy)propane-1,2-diyl dioleate(22202-46-6)
• EPA Substance Registry System: (Z)-(S)-3-(trityloxy)propane-1,2-diyl dioleate(22202-46-6)

Safety Data

• Hazardous Substances Data: 22202-46-6(Hazardous Substances Data)

Upstream product

• 112-80-1 cis-Octadecenoic acid 
• 16975-62-5 (R)-3-(trityloxy)propane-1,2-diol 
• 26156-84-3 N-tritylpyridinium tetrafluoroborate 
• 112-77-6 (Z)-9-octadecenoyl chloride 
• 16975-61-4 (R)-2,2-dimethyl-4-trityloximethyl-[1,3]dioxolane 
• 17327-05-8 (S)-3-(trityloxy)propane-1,2-diol 
• 16975-62-5 tritylglycerol 
• 111247-96-2 methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate 
• 17327-06-9 (R)-4-(triphenylmethoxy)methyl-1,3-dioxolan-2-one 

Downstream Products

• 4235-95-4 dioleoylphosphatidylcholine 

Relevant articles and documents

Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation

Natural phosphatidylserine (PS), which contains two chiral centers, enhances blood coagulation. However, the process by which PS enhanced blood coagulation is not completely understood. An efficient and flexible synthetic route has been developed to synthesize all of the possible stereoisomers of PS. In this study, we examined the role of PS chiral centers in modulating the activity of the tissue factor (TF)-factor VIIa coagulation initiation complex. Full length TF was relipidated with phosphatidylcholine, and the synthesized PS isomers were individually used to estimate the procoagulant activity of the TF-FVIIa complex via a FXa generation assay. The results revealed that the initiation complex activity was stereoselective and had increased sensitivity to the configuration of the PS glycerol backbone due to optimal protein-lipid interactions.

Synthesis of phosphatidyl-α-glucosyl glycerol containing a dioleoyl phosphatidyl moiety. Application of the tetraisopropyldisiloxane-1,3-diyl (tips) protecting group in sugar chemistry. part III1 1 For part I and II see references 11 and 39, respectively.

In this study we demonstrate that the tetraisopropyldisiloxane-1,3-diyl protecting group could be introduced, in a two step procedure, at the 3'- and 4'-hydroxyl functions of α-glucosyldiglyceride 3 to give derivative 6. Compound 6 could be selectively condensed with a suitably protected phosphatidyl part 9 at its primary hydroxyl function to afford the protected glycophospholipid 10a. The phosphatidyl part 9 was obtained by phosphorylation of optically pure 1,2-di-O-oleoyl-sn-glycerol (8a) with phosphoditriazolide 7b. Finally, the 2,4-dichlorophenyl and TIPS protecting groups were removed from 10a by syn-4-nitro-benzaldoximate and fluoride ions, respectively, to afford glycophospholipid 10c.