22236-45-9Relevant articles and documents
Carr et al.
, p. 477 (1969)
Copper-catalyzed imination of sulfoxides and sulfides
Liu, Yuanyuan,Wang, Hanying,Yang, Xianjin
supporting information, p. 4697 - 4702 (2019/07/22)
Sulfoximines and sulfilimines have attracted considerable interest among organic chemists. The Cu(II)-catalyzed imination of sulfoxides and sulfides using various N-fluoro benzenesulfonamides was investigated in this study. The scope of the reaction was demonstrated by using several substituted sulfides and sulfoxides. The flow strategy for the preparation of NH-sulfoximines was also examined. By trapping nitrene intermediates through triphenylphosphine, we found that the reaction was conducted through a metal-nitrene intermediate mechanism.
General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor
Goldberg, Frederick W.,Kettle, Jason G.,Xiong, Jian,Lin, Daoguang
, p. 6613 - 6622 (2015/03/30)
The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clinical candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesising a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, commercially available precursor is discussed.
Preparation of N-(Arylsulfonyl)sulfoximines by Oxidation of N-(Arylsulfonyl)sulfilimines with Sodium Hypochlorite in a Two-Phase System
Akutagawa, Kunihiko,Furukawa, Naomichi,Oae, Shigeru
, p. 2282 - 2284 (2007/10/02)
-