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22245-83-6

22245-83-6

Identification

Synonyms:LDP51:2-Hydroxy-3- Trifluoromethyl Pyridine;2-Hydroxy-3-trifluoromethyl -pyridine;2-Hydroxy-3-trifluoromethyl pyridine;2-Hydroxy-3- Trifluoromethyl Pyridine;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi,HarmfulXn

  • Hazard Codes:Xi,Xn,T

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Hydroxy-3-trifluoromethylpyridine
  • Packaging:1g
  • Price:$ 70
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:3-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-(Trifluoromethyl)-2-pyridone >98.0%(GC)(T)
  • Packaging:1g
  • Price:$ 43
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Hydroxy-3-(trifluoromethyl)pyridine 98%
  • Packaging:5 g
  • Price:$ 15
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Hydroxy-3-(trifluoromethyl)pyridine 98%
  • Packaging:25 g
  • Price:$ 60
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:2-Hydroxy-3-trifluoromethylpyridine
  • Packaging:25 g
  • Price:$ 625
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Hydroxy-3-(trifluoromethyl)pyridine 97%
  • Packaging:25g
  • Price:$ 98
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
  • Packaging:1kg
  • Price:$ 2567
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
  • Packaging:500g
  • Price:$ 1717
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE 98
  • Packaging:100g
  • Price:$ 750
  • Delivery:In stock
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Relevant articles and documentsAll total 10 Articles be found

Deoxofluorination of (Hetero)aromatic Acids

Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.

, p. 3110 - 3124 (2020/03/23)

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

ANDROGEN RECEPTOR MODULATOR FOR TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES

-

Paragraph 0055-0056, (2016/11/14)

PROBLEM TO BE SOLVED: To provide a series of compounds that modulate the function of the nuclear hormone receptors, especially the androgen receptor. SOLUTION: The present invention relates to hydantoin compounds, methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example, prostate cancer, and to pharmaceutical compositions containing such compounds. In an embodiment, a pharmaceutical composition includes a therapeutically effective amount of a compound according to the formula II, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant. The present invention provides a series of compounds that modulate the function of the nuclear hormone receptors, especially the androgen receptor. These compounds can cause disappearance of prostate cancer cells and tumors. COPYRIGHT: (C)2016,JPOandINPIT

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

-

Paragraph 0169; 0170, (2013/03/26)

Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

Process route upstream and downstream products

Process route

2-hydroxypyridin
142-08-5

2-hydroxypyridin

iodotrifluoromethane
2314-97-8,263005-66-9

iodotrifluoromethane

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
Conditions Yield
With ferrocene; dihydrogen peroxide; dimethyl sulfoxide; In water; at 40 - 50 ℃; for 0.333333h;
50%
With ferrocene; dihydrogen peroxide; In water; dimethyl sulfoxide;
68 %Spectr.
2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
Conditions Yield
With potassium hydroxide; In tert-butyl alcohol; for 10h; Heating;
73%
2-chloro-3-trifluoromethyl-pyridine; With potassium hydroxide; In tert-butyl alcohol; at 20 - 90 ℃;
With acetic acid; In tert-butyl alcohol;
Multi-step reaction with 3 steps
1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave
2: ammonia / water / 10 h / 130 °C / 22502.3 Torr
3: sodium nitrite; hydrogenchloride / water / 3 h / 0 °C
With hydrogenchloride; hydrogen fluoride; ammonia; sodium nitrite; In water;
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
Conditions Yield
With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 3h; Temperature;
2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

Conditions
Conditions Yield
With acetic acid; In water; for 168h; Reflux;
93%
With acetic acid; In water; for 168h; Reflux;
93%
Multi-step reaction with 2 steps
1: 71 percent / NH3 / H2O / 24 h / 175 °C
2: 69 percent / H2SO4, NaNO2 / H2O / 1 h / 70 °C
With sulfuric acid; ammonia; sodium nitrite; In water;
With potassium hydroxide; In tert-butyl alcohol; at 90 ℃;
5.8 g
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

Conditions
Conditions Yield
With sulfuric acid; sodium nitrite; In water; at 70 ℃; for 1h;
69%
1,2-dihydro-2-oxonicotinic acid
609-71-2

1,2-dihydro-2-oxonicotinic acid

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

Conditions
Conditions Yield
With sulfur tetrafluoride; hydrogen fluoride; at 85 ℃; for 24h; Autoclave; Inert atmosphere;
79%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

α-bromoacetophenone
70-11-1

α-bromoacetophenone

C<sub>14</sub>H<sub>10</sub>F<sub>3</sub>NO<sub>2</sub>

C14H10F3NO2

Conditions
Conditions Yield
3-(trifluoromethyl)pyridin-2-ol; With sodium hydride; In dimethyl sulfoxide; for 0.166667h;
α-bromoacetophenone; In dimethyl sulfoxide; at 20 ℃; for 3h;
benzyl bromide
100-39-0

benzyl bromide

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

C<sub>13</sub>H<sub>9</sub>F<sub>3</sub>INO

C13H9F3INO

Conditions
Conditions Yield
3-(trifluoromethyl)pyridine-2-(1H)-one; With N-iodo-succinimide; acetic acid; In acetonitrile; at 65 ℃; for 5h;
benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
88%
benzyl bromide
100-39-0

benzyl bromide

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

1-benzyl-3-(trifluoromethyl)pyridin-2(1H)-one

1-benzyl-3-(trifluoromethyl)pyridin-2(1H)-one

Conditions
Conditions Yield
With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
71%
1-{[4-(chloromethyl)phenyl]methyl}-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide

1-{[4-(chloromethyl)phenyl]methyl}-N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)pyrazole-4-carboxamide

3-(trifluoromethyl)pyridine-2-(1H)-one
22245-83-6

3-(trifluoromethyl)pyridine-2-(1H)-one

N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[(4-{[2-oxo-3-(trifluoromethyl)pyridin-1-yl]methyl}phenyl)methyl]pyrazole-4-carboxamide

N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-[(4-{[2-oxo-3-(trifluoromethyl)pyridin-1-yl]methyl}phenyl)methyl]pyrazole-4-carboxamide

Conditions
Conditions Yield
With potassium carbonate; Inert atmosphere;
63%

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