223389-16-0

Basic information

• Product Name: Ethanone, 1-furo[2,3-c]pyridin-5-yl- (9CI)
• Synonyms: Ethanone, 1-furo[2,3-c]pyridin-5-yl- (9CI);1-(furo[2,3-c]pyridin-5-yl)ethanone
• CAS NO: 223389-16-0
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.15738
• Product Categories: ACETYLGROUP
• Mol File: 223389-16-0.mol

Chemical Properties

• Boiling Point: 268.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• PKA: 2.81±0.40(Predicted)
• CAS DataBase Reference: Ethanone, 1-furo[2,3-c]pyridin-5-yl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-furo[2,3-c]pyridin-5-yl- (9CI)(223389-16-0)
• EPA Substance Registry System: Ethanone, 1-furo[2,3-c]pyridin-5-yl- (9CI)(223389-16-0)

Safety Data

• Hazardous Substances Data: 223389-16-0(Hazardous Substances Data)

Upstream product

• 223389-14-8 5-ethoxycarbonylfuro[2,3-c]pyridine 
• 917-54-4 methyllithium 
• 540-88-5 acetic acid tert-butyl ester 
• 223389-17-1 ethyl β-oxo-5-furo[2,3-c]pyridinepropionate 
• 185220-77-3 5-(1-hydroxyethyl) furo[2,3-c]pyridine 
• 185221-57-2 (R)-5-(1-hydroxyethyl)furo[2,3-c]-pyridine 
• 93001-59-3 N-(3-methyl-furan-2-ylmethylene)-aniline 
• 33342-48-2 3-methyl-2-furfuraldehyde 

Relevant articles and documents

Purification and characterization of an NADH-dependent alcohol dehydrogenase from Candida maris for the synthesis of optically active 1-(pyridyl)ethanol derivatives

A novel (R)-specific alcohol dehydrogenase (AFPDH) produced by Candida maris IFO10003 was purified to homogeneity by ammonium sulfate fractionation, DEAE-Toyopearl, and Phenyl-Toyopearl, and characterized. The relative molecular mass of the native enzyme was found to be 59,900 by gel filtration, and that of the subunit was estimated to be 28,900 on SDS-polyacrylamide gel electrophoresis. These results suggest that the enzyme is a homodimer. It required NADH as a cofactor and reduced various kinds of carbonyl compounds, including ketones and aldehydes. AFPDH reduced acetylpyridine derivatives, β-keto esters, and some ketone compounds with high enantioselectivity. This is the first report of an NADH-dependent, highly enantioselective (R)-specific alcohol dehydrogenase isolated from a yeast. AFPDH is a very useful enzyme for the preparation of various kinds of chiral alcohols.

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

Method for producing pyridine derivatives

A pyridine alcohol derivative represented by General Formula III (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together wit

Intermediates for producing pyridine derivatives

A pyridine alcohol derivative represented by General Formula III (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together wit