2237-36-7

Basic information

• Product Name: 4-Methoxysalicylic acid
• Synonyms: RARECHEM AL BE 0038;ASISCHEM D13357;4-METHOXYSALICYLIC ACID;AKOS 210-04;2-HYDROXY-4-METHOXYBENZOIC ACID;2-HYDROXY-P-ANISIC ACID;P-MethoxysalicylicAcid;2-Hydroxy-4-MethoxybenzoicAcid(P-MethoxysalicylicAcid)
• CAS NO: 2237-36-7
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.15
• EINECS: 218-801-0
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Pyrroles
• Mol File: 2237-36-7.mol
• Article Data: 31

Chemical Properties

• Melting Point: 158-159 °C(lit.)
• Boiling Point: 217.07°C (rough estimate)
• Flash Point: 137.9 °C
• Appearance: Off-white to beige/Powder
• Density: 1.1816 (rough estimate)
• Vapor Pressure: 7.5E-05mmHg at 25°C
• Refractive Index: 1.4611 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.22±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxysalicylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxysalicylic acid(2237-36-7)
• EPA Substance Registry System: 4-Methoxysalicylic acid(2237-36-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• RTECS: DH2270000
• Hazardous Substances Data: 2237-36-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige powder

Uses

2-Hydroxy-4-methoxybenzoic acid (4-methoxysalicylic acid) was used in the synthesis of 1,3,4-oxadiazole derivatives.

InChI:InChI=1/C8H8O4/c1-12-5-2-3-6(8(10)11)7(9)4-5/h2-4,9H,1H3,(H,10,11)/p-1

Upstream product

• 89-86-1 4-hydroxysalicylic acid 
• 77-78-1 dimethyl sulfate 
• 29107-21-9 (7-methoxy-4-oxo-4H-chromen-3-yl)-acetic acid 
• 67029-83-8 3,7-dimethoxy-chromen-4-one 
• 64-19-7 acetic acid 
• 574-03-8 kanugin 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 123-62-6 propionic acid anhydride 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 51-01-4 2,4-bis(acetyloxy)benzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 59648-29-2 2-hydroxy-4-methoxybenzyl alcohol 
• 67-56-1 methanol 

Downstream Products

• 55085-15-9 2-ethoxy-4-methoxy-benzoic acid 
• 131-54-4 bis(2-hydroxy-4-methoxyphenyl)-methanone 
• 35031-00-6 ethyl 2-hydroxy-4-methoxybenzoate 
• 109156-73-2 2-(2,4-dimethoxy-benzoyloxy)-4-methoxy-benzoic acid 
• 98437-41-3 5-bromo-2-hydroxy-4-methoxybenzoic acid 
• 5981-37-3 2,5-dihydroxy-4-methoxybenzoic acid 
• 5446-02-6 4-methoxymethylsalicylate 
• 723284-11-5 2-hydroxy-4-methoxy-5-nitrobenzoic acid 
• 99114-88-2 2-hydroxy-4-methoxy-5-sulfo-benzoic acid 
• 17336-11-7 2-acetoxy-4-methoxybenzoic acid 
• 6131-38-0 2-hydroxy-4,4'-dimethoxybenzophenone 
• 109563-16-8 2-hydroxy-4-methoxy-benzoic acid-(4-nitro-anilide) 
• 109563-37-3 2-hydroxy-4-methoxy-benzoic acid-(2-nitro-anilide) 
• 53929-76-3 2-hydroxy-4-methoxy-benzoic acid anilide 

Relevant articles and documents

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SEMECARPETIN, A BIFLAVANONE FROM SEMECARPUS ANACARDFIUM

Key Word Index - Semecarpus anacardium; Anacardiceae; biflavanones; 1H NMR and mass spectra; semecarpetin.Abstract - A new biflavanone, semecarpetin, has been recently isolated from the nut shells of Semecarpus anacardium.Its structure has been characterized on the basis of spectral and chemical data as 7''-hydroxy-7,3''',4',4'''-tetramethoxybi(8'',3')flavanone.

Catalytic oxidation of alcohols and alkyl benzenes to carbonyls using Fe3O4?SiO2?(TEMPO)-: Co -(Chlorophyll-CoIII) as a bi-functional, self-co-oxidant nanocatalyst

Chlorophyll b was extracted from heliotropium europaeum plant, demetalated, allylated and grafted to acrylated TEMPO through a copolymerization protocol. Then, the chlorophyll monomers were coordinated to Co ions, immobilized on magnetic nanoparticles and the resulting hybrid was used as a powerful catalyst for a variety of oxidation reactions. By using the present method, oxidation of benzylic alcohols and alkyl benzenes to carbonyls was accomplished in water under aerobic conditions. Moreover, direct oxidation of alcohols to carboxylic acids was performed by adding NaOCl to the mixture. All entries were oxidized to the corresponding desired product with high to excellent yields and up to 97% selectivity. The catalyst was thoroughly characterized by CV, TGA, VSM, XRD, XPS, DLS, FE-SEM, TEM, UV-Vis, EDX, and BET analyses. The activity of the catalyst was investigated by applying various components of the catalyst to the oxidation model separately. The reasonable mechanisms are suggested based on the cooperation between the TEMPO groups and cobalt(iii) (or Co(iv)) sites on the catalyst. The catalyst could be recovered and reused for at least 7 consecutive recycles without any considerable reactivity loss. This journal is

Synthetic method of 4-methoxysalicylic acid

The invention belongs to the technical field of organic chemical synthesis and discloses a synthetic method of 4-methoxysalicylic acid, comprising the steps of (1) reacting for preparation, to be specific, adding 2,4-dihydroxybenzoic acid into methanol solution of sodium methylate, dropwise adding methyl p-toluenesulfonate, and stirring the reaction solution; (2) distilling, to be specific, distilling the reaction solution of step (1), and removing methanol; (3) acidifying, to be specific, pouring the reaction solution of step (2) into an ice water mixture with hydrochloric acid, and stirring;(4) filtering and cleaning, to be specific, filtering the mixture of step (3), and cleaning with water to obtain crude 4-methoxysalicylic acid. The methyl p-toluenesulfonate having little toxicity isused to replace highly toxic dimethyl sulfate; the sodium methylate is used as a catalyst; few byproducts are produced; the preparation process is simple; little wastewater is generated; light pollution is caused; the prepared 4-methoxysalicylic acid has high purity and high yield.