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2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methyl-, also known as Temozolomide, is a chemotherapeutic agent specifically designed for the treatment of brain tumors, including malignant gliomas and metastatic melanoma. It functions by damaging the DNA of cancer cells, leading to their death. As an oral medication, Temozolomide is often combined with other treatments like radiation therapy to enhance its effectiveness. However, it is associated with common side effects such as nausea, vomiting, fatigue, and low blood cell counts, necessitating close monitoring by healthcare professionals due to its potential for serious side effects.

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  • 22441-52-7 Structure
  • Basic information

    1. Product Name: 2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methyl-
    2. Synonyms:
    3. CAS NO:22441-52-7
    4. Molecular Formula: C7H9ClN2O2
    5. Molecular Weight: 188.61200
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 22441-52-7.mol
  • Chemical Properties

    1. Melting Point: 203-205 °C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.284±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methyl-(22441-52-7)
    11. EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methyl-(22441-52-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 22441-52-7(Hazardous Substances Data)

22441-52-7 Usage

Uses

Used in Oncology:
2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methylis used as a chemotherapeutic agent for the treatment of brain tumors, specifically malignant gliomas and metastatic melanoma, due to its ability to damage the DNA of cancer cells, resulting in cell death.
Used in Combination Therapy:
In the field of oncology, 2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methylis used in combination with radiation therapy to enhance the effectiveness of cancer treatment, as it can work synergistically with other treatments to improve patient outcomes.
Used in Medication Development:
2,4(1H,3H)-Pyrimidinedione, 1-(2-chloroethyl)-5-methylis also used in the development of new medications and therapies for cancer treatment, given its established role in damaging cancer cell DNA and its potential for combination with other agents to increase therapeutic efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 22441-52-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,4 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22441-52:
(7*2)+(6*2)+(5*4)+(4*4)+(3*1)+(2*5)+(1*2)=77
77 % 10 = 7
So 22441-52-7 is a valid CAS Registry Number.

22441-52-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-chloroethyl)-5-methylpyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22441-52-7 SDS

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