224580-59-0Relevant articles and documents
Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B
Aggarwal, Varinder K.,Bae, Imhyuck,Lee, Hee-Yoon
, p. 9725 - 9733 (2007/10/03)
Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. Graphical abstract.
Synthesis of prelactone B
Hanefeld,Hooper,Staunton
, p. 401 - 403 (2007/10/03)
Prelactone B (1a) and its isomer 1b are possible products of a truncated avermectin polyketide synthase. In order to make them available as reference compounds they were synthesized in a six-step synthesis with 56% overall yield.