2251-50-5Relevant articles and documents
3,28-Bis-O-polyfluorobenzoylbetulin. Synthesis, Molecular Structure, and Cytotoxicity
Trishin, Yu. G.,Fedorov,Lyssenko,Prokof’eva,Rudenok, Yu. S.,Pavlova
, p. 1480 - 1485 (2018)
Treatment of betulin with 2,3,4,5-tetrafluoro- and pentafluorobenzoyl chlorides in triethylamine afforded 3,28-bis-O-polyfluorobenzoylbetulins. According to the X-ray diffraction data, all six-membered rings in the 3,28-bis-O-pentafluorobenzoylbetulin molecule appear in a chair conformation, and the five-membered ring has an envelope conformation with the C17 atom deviating from the plane formed by the other four carbon atoms. Unlike betulin itself, the obtained bis-esters showed no cytotoxic effect on human lung adenocarcinoma cell line A549 and human glioblastoma cell line U251.
Preparation method of benzoyl chloride compound
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Paragraph 0074-0078, (2021/06/22)
The invention provides a preparation method of a benzoyl chloride compound. The preparation method comprises the following step: with a trichloromethyl benzene compound and a benzoic acid compound as raw materials and ferric oxide as a catalyst, carrying out a catalytic reaction to prepare the benzoyl chloride compound. According to the method disclosed by the invention, the benzoyl chloride compound can be obtained under the condition of not using a solvent, yield is up to 95% or above, atom economy is good, cost is lower, operation is simpler, more convenient and safer, the treatment amount of three wastes is smaller, the three wastes is easier to treat, and the method is more suitable for industrial production.
Synthesis of N-trifluoromethyl amides from carboxylic acids
Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.
supporting information, p. 2245 - 2255 (2021/08/12)
Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.
Perfluoropolyether ester derivative as well as preparation method and application thereof
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Paragraph 0027-0029, (2020/06/20)
The invention discloses a perfluoropolyether ester derivative as well as a preparation method and application thereof. The preparation method of the perfluoropolyether ester derivative comprises the following steps: (1) performing acyl chlorination on pentafluorobenzoic acid to obtain pentafluorobenzoyl chloride; and (2) carrying out an esterification reaction on the pentafluorobenzoyl chloride and perfluoropolyether alcohol to obtain the perfluoropolyether ester derivative. In perfluoropolyether derivative molecules provided by the invention, a perfluoropolyether part provides compatibility with perfluoropolyether, and an ester group and a pentafluorophenyl part provide enhanced lubricity and bearing capacity; a large number of fluorine atoms contained in molecules can better generate friction chemical reaction with the metal surface, so that a film structure is easily formed on the surface of a friction pair, and the lubricating effect is promoted. The perfluoropolyether derivative also has good thermal stability and can still keep a certain lubricating effect at 150 DEG C. The perfluoropolyether ester derivative has good antifriction and antiwear properties when used as a lubricating grease additive.