225112-10-7

Basic information

• Product Name: 3-<(Benzyloxycarbonyl)amino>-8-methyl-4H-pyrido<1,2-a>pyrimidin-4-one
• Synonyms: 3-<(Benzyloxycarbonyl)amino>-8-methyl-4H-pyrido<1,2-a>pyrimidin-4-one
• CAS NO: 225112-10-7
• Molecular Weight: 309.324
• Mol File: 225112-10-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-<(Benzyloxycarbonyl)amino>-8-methyl-4H-pyrido<1,2-a>pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<(Benzyloxycarbonyl)amino>-8-methyl-4H-pyrido<1,2-a>pyrimidin-4-one(225112-10-7)
• EPA Substance Registry System: 3-<(Benzyloxycarbonyl)amino>-8-methyl-4H-pyrido<1,2-a>pyrimidin-4-one(225112-10-7)

Safety Data

• Hazardous Substances Data: 225112-10-7(Hazardous Substances Data)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 219739-90-9 Methyl (Z)-2-<(benzyloxycarbonyl)amino>-3-dimethylaminopropenoate 
• 100-51-6 benzyl alcohol 
• 34662-59-4 8-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 1212-53-9 methyl N-benzyloxycarbonylglycinate 

Relevant articles and documents

Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors

Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluat

Methyl (Z)-2-[(benzyloxycarbonyl)amino]-3-dimethyl-aminopropenoate in the synthesis of heterocyclic systems. Synthesis of (benzyloxycarbonyl)amino substituted fused pyrimidinones

Methyl (Z)-2-[(benzyloxycarbonyl)amino]-3-dimethylaminopropenoate (1) was used as a reagent for preparation of 3-[(benzyloxycarbonyl)amino] substituted 4H-pyrido[1,2-a]pyrimidin-4-ones 17-21, 4H-pyrimido[1,2-b]pyridazin-4-ones 22 and 23, 5H-[1,2,4]triazolo[2,3-a]-pyrimidin-5-one 24, 5H-thiazolo[3,2-a]pyrimidin-5-one 25, and 4H-pyrazino[1,2-a]pyrimidin-4-one 26. Removal of the benzyloxycarbonyl group by catalytical transfer hydrogenation with Pd/C in the presence of cyclohexene is selective to give 3-amino-4H-pyrido[1,2-a]-pyrimidin-4-ones 27-30 in 85-92% yields, or with hydrogen bromide in acetic acid to give 3-amino-4H-pyrimido[1,2-b]pyridazin-4-one (31) and 6-amino-5H-thiazolo[3,2-a]pyrimidin-5-one (32) in 80% yields.