22543-21-1

Basic information

• Product Name: 2-methoxypropanamide
• Synonyms: 2-methoxypropanamide
• CAS NO: 22543-21-1
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.11976
• Mol File: 22543-21-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-methoxypropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxypropanamide(22543-21-1)
• EPA Substance Registry System: 2-methoxypropanamide(22543-21-1)

Safety Data

• Hazardous Substances Data: 22543-21-1(Hazardous Substances Data)

Upstream product

• 17639-76-8 methyl 2-methoxypropionate 
• 61915-18-2 R-(+)-2-methoxypropionic acid chloride 
• 5445-17-0 Methyl 2-bromopropionate 
• 124-41-4 sodium methylate 
• 4324-39-4 ethyl 2-methoxypropionate 
• 33695-59-9 2-methoxy-propanenitrile 

Downstream Products

• 33695-59-9 2-methoxy-propanenitrile 
• 299396-92-2 (R)-2-methoxy-propionitrile 
• 7664-41-7 ammonia 
• 75-07-0 acetaldehyde 
• 3124-96-7 R,S-2-methoxypropyl amine 

Relevant articles and documents

The Influence of Borate Buffers on the Hydration Rate of Cyanohydrins: Evidence for an Intramolecular Mechanism

The effects of borate buffers on the pseudo first-order rate constants for the hydration of hydroxyacetonitrile (1) have been examined on the pH range 8.6-10.3 at 80 deg C.Kinetic results are compatible with a reaction of the neutral cyanohydrin with borate anion or any other kinetically equivalent mechanism.Cyanohydrin structural effects are consistent with a pathway involving the pre-equilibrium formation of a borate-substrate adduct, followed by a rate-determining intramolecular nucleophilic attack on the nitrile group.Phenylboronate ion has also been shown to act as an efficient catalyst, but it was not possible to detect any influence due to disubstituted borate ions.Thus, it is suggested that a trigonal borate anion actually acts as a nucleophile.