226249-16-7

Basic information

• Product Name: (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide
• Synonyms: (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide;N-(pyrrolidine-(3R)-yl-carbamoylmethyl)-3-trifluoromethylbenzamide;Benzamide, N-[2-oxo-2-[(3R)-3-pyrrolidinylamino]ethyl]-3-(trifluoromethyl)-
• CAS NO: 226249-16-7
• Molecular Formula: C₁₄H₁₆F₃N₃O₂
• Molecular Weight: 315.2909496
• Mol File: 226249-16-7.mol

Chemical Properties

• Boiling Point: 518.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 12.94±0.46(Predicted)
• CAS DataBase Reference: (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide(226249-16-7)
• EPA Substance Registry System: (R)-N-(2-oxo-2-(pyrrolidin-3-ylaMino)-ethyl)-3-(trifluoroMethyl)benzaMide(226249-16-7)

Safety Data

• Hazardous Substances Data: 226249-16-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide is used as a research chemical for exploring its potential pharmaceutical applications. The presence of the trifluoromethyl and pyrrolidin-3-ylamino groups in its structure suggests that it may possess biological activity, making it a promising candidate for the development of new drugs.
Used in Drug Development:
In the pharmaceutical industry, (R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide is used as a starting point for the development of novel drugs. Its unique molecular structure and potential biological activity make it an interesting compound for further research and development, with the aim of creating new therapeutic agents.
Used in Chemical Synthesis:
(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide may also be used as an intermediate in the synthesis of other complex organic compounds. Its unique functional groups can be utilized in various chemical reactions, potentially leading to the creation of new molecules with specific applications in different industries.

Upstream product

• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 17794-48-8 m-trifluoromethylhippuric acid 
• 226228-88-2 (R)-N-(2-(1-benzylpyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide 

Downstream Products

• 1261061-76-0 N-{[1-(2-hydroxybutyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide 
• 1261061-73-7 N-{[1-(2-(4-tert-butoxycarbonylpiperazine-1-yl)ethyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide 
• 1226894-91-2 N-{[1-(1-(4-benzoylpiperazine-1-yl)propane-2-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide 
• 1226894-92-3 N-{[1-(1-(4-benzoylpiperazine-1-yl)butane-2-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide 
• 1261061-75-9 N-{[1-(2-hydroxypropyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide 

Relevant articles and documents

PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST

The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteri

PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST

The present invention relates to compounds of chemical formula I and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteri

Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist

We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC 50 of 4.7 nM in antagonism of c

Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists

Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure-activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compo

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series

SAR studies were conducted around lead compound 1 using high-throughput parallel solution and solid phase synthesis. Our lead optimization efforts led to the identification of several CCR2b antagonists with potent activity in both binding and functional a