22707-38-6

Basic information

• Product Name: 1-butanoylpyrrolidin-2-one
• Synonyms: 1-butanoylpyrrolidin-2-one
• CAS NO: 22707-38-6
• Molecular Formula: C8H13NO2
• Molecular Weight: 0
• Mol File: 22707-38-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 272.5°Cat760mmHg
• Flash Point: 118.7°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 0.00606mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: 1-butanoylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butanoylpyrrolidin-2-one(22707-38-6)
• EPA Substance Registry System: 1-butanoylpyrrolidin-2-one(22707-38-6)

Safety Data

• Hazardous Substances Data: 22707-38-6(Hazardous Substances Data)

Usage

Chemical compound

Yes

Type of derivative

Pyrrolidinone derivative

Usage

Precursor in the synthesis of pharmaceutical compounds

Physical appearance

White, crystalline solid

Melting point

Around 90-93°C

Applications

a. Pharmaceutical intermediate in drug production
b. Reagent in organic synthesis

Safety precautions

Handle with care and use appropriate safety measures due to potential health and environmental hazards.

InChI:InChI=1/C8H13NO2/c1-2-4-7(10)9-6-3-5-8(9)11/h2-6H2,1H3

Upstream product

• 616-45-5 2-pyrrolidinon 
• 141-75-3 butyryl chloride 
• 106-31-0 butanoic acid anhydride 

Relevant articles and documents

Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives

Several 1-acyl-2-pyrrolidinone derivatives were synthesized as derivatives of γ-aminobutyric acid (GABA), and their pharmacological activities and stabilities were investigated. The derivatives showed anticonvulsant effect on picrotoxin-induced seizure at a dose of 200 mg/kg. In particular, 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) had a high activity. The anticonvulsant activity showed a dose dependency. Some of 1-acyl-2-pyrrolidinone derivatives prolonged sleeping time which was induced by sodium pentobarbital and showed a recovery from disruption of the memory of passive avoidance response, which was induced by an electroconvulsive shock. As shown by the results of the stability study of 1-acetyl-2-pyrrolidinone (1), it was degraded in an acidic buffer and an alkaline buffer although 2-pyrrolidinone was stable. 1-Acyl-2-pyrrolidinone derivatives were degraded in liver and brain homogenates of mouse and rat. They showed a degradation rate in rat plasma. Conversion of 8 to GABA in mouse liver homogenate was demonstrated. These results suggested that the pharmacological activity of 1-acyl-2-pyrrolidinone is probably due to the release of GABA by hydrolysis of derivatives although further work is necessary.