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2274-66-0

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2274-66-0 Usage

Uses

2,2-Dichloro-1-(2,4-dichlorophenyl)ethanone is used in the synthesis of acid chloride phenylhydrazones in a broad-spectrum anthelmintic series.

Check Digit Verification of cas no

The CAS Registry Mumber 2274-66-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,7 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2274-66:
(6*2)+(5*2)+(4*7)+(3*4)+(2*6)+(1*6)=80
80 % 10 = 0
So 2274-66-0 is a valid CAS Registry Number.

2274-66-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-dichloro-1-(2,4-dichlorophenyl)ethanone

1.2 Other means of identification

Product number -
Other names 2,4-Dichlorophenacylidene chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2274-66-0 SDS

2274-66-0Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Zhang, Shao-Lin,Yang, Zheng,Hu, Xiaohui,Tam, Kin Yip

supporting information, p. 3441 - 3445 (2018/09/29)

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

Preparation of carbon-14 labeled organophosphate pesticides: Chlorfenvinphos

Fudala, Louise,Lewin, Anita H.

, p. 261 - 266 (2007/10/03)

Synthesis of [vinyl-14C]chlorfenvinphos, utilizing [14C]iodomethane as the source of the label, was accomplished in 28% radiochemical yield by the methylation of 2,4-dichlorobenzoyl chloride, chlorination of the resulting [14C]-2,4-dichloroacetophenone, and condensation of the product with triethylphosphite. The product, isolated as a mixture of E and Z isomere (3.6 and 96.3%, respectively), was obtained in >99% purity and had specific activity 20 mCl/mmol.

NOVEL FRIEDEL-CRAFTS REACTIONS OF SOME ARENES

Mahato, Shashi B.,Mandal, Nirup B.,Pal, Anil K.,Maitra, Swapan K.

, p. 4439 - 4446 (2007/10/02)

The novel secondary Friedel-Crafts acylation products of the arenes, dimethyl resorcinol, m-xylene, m-methylanisole and m-chlorotoluene using dichloroacetylchloride and anhydrous AlCl3 are described.The formation of the unexpected products has been shown to depend on the nucleophilicity of the arene and the electrophilicity of the acyl carbonyl of the initially formed acylated product.Higher molar proportion of the arene and sometimes elevated temperature are necessary for generation of the products.The reaction pathway has been shown to be influenced by the formation of the possible complex of AlCl3 and dichloroacetylchloride with the groups adjacent to the dichloroacetyl function, especially at higher temperature.Dimethylresorcinol yields the unique products 4, 5, 6, 7 and 9 and m-xylene, m-methylanisole and m-chlorotoluene furnish 10, 13 and 15 respectively.Electronic factors responsible for generation of the products and rationalisation of their formation are discussed.

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