227626-55-3

Basic information

• Product Name: Cyclohexaneacetonitrile, 1-(nitromethyl)-
• CAS NO: 227626-55-3
• Molecular Formula: C9H14N2O2
• Molecular Weight: 182.222
• Mol File: 227626-55-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclohexaneacetonitrile, 1-(nitromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexaneacetonitrile, 1-(nitromethyl)-(227626-55-3)
• EPA Substance Registry System: Cyclohexaneacetonitrile, 1-(nitromethyl)-(227626-55-3)

Safety Data

• Hazardous Substances Data: 227626-55-3(Hazardous Substances Data)

Upstream product

• 108-20-3 di-isopropyl ether 
• 4435-18-1 2-cyclohexylideneacetonitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 1-AMINOMETHYL-1- CYCLOHEXANEACETIC ACID

A process for the preparation of gabapentin of formula (I) which comprises: a) reduction of (1-nitromethyl-cyclohexyl)acetonitrile of formula (II) to give 3-imino-2-aza-spiro[4.5]decan-2-ol of formula (III) b) transformation of compound (III), by alkali treatment, into 2-hydroxy-2-aza-spiro[4.5]decan-3-one of formula (IV) c) reduction of compound (IV) to give 2-aza-spiro[4.5]decan-3-one of d) hydrolysis of compound (V) to gabapentin.

1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders

Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; A′ is a bridged ring selected from (1), (2), (3), (4), (5) wherein is the point of attachment; Z1to Z4are each independently selected from hydrogen and methyl; o is an integer of from 1 to 4; and p is an integer of from 0 to 2. In formula (1) above R cannot be sulfonic acid when m is 2 and n is 1 are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, especially irritable bowel syndrome.