229343-22-0Relevant articles and documents
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa
Kochanny, Monica J.,Adler, Marc,Ewing, Janice,Griedel, Brian D.,Ho, Elena,Karanjawala, Rushad,Lee, Wheeseong,Lentz, Dao,Liang, Amy M.,Morrissey, Michael M.,Phillips, Gary B.,Post, Joseph,Sacchi, Karna L.,Sakata, Steven T.,Subramanyam, Babu,Vergona, Ron,Walters, Janette,White, Kathy A.,Whitlow, Marc,Ye, Bin,Zhao, Zuchun,Shaw, Kenneth J.
, p. 2127 - 2146 (2008/02/01)
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inhibito