2294-75-9Relevant articles and documents
Enantioselective Alkylation of 2-Alkylpyridines Controlled by Organolithium Aggregation
Gladfelder, Joshua J.,Ghosh, Santanu,Podunavac, Ma?a,Cook, Andrew W.,Ma, Yun,Woltornist, Ryan A.,Keresztes, Ivan,Hayton, Trevor W.,Collum, David B.,Zakarian, Armen
supporting information, p. 15024 - 15028 (2019/10/22)
Direct enantioselective α-alkylation of 2-alkylpyridines provides access to chiral pyridines via an operationally simple protocol that obviates the need for prefunctionalization or preactivation of the substrate. The alkylation is accomplished using chiral lithium amides as noncovalent stereodirecting auxiliaries. Crystallographic and solution NMR studies provide insight into the structure of well-defined chiral aggregates in which a lithium amide reagent directs asymmetric alkylation.
Nickel-catalyzed reductive alkylation of halogenated pyridines with secondary alkyl bromides
Liu, Huiyan,Liang, Zhuye,Qian, Qun,Lin, Kunhua
supporting information, p. 2999 - 3007 (2014/10/16)
This article highlights Ni-catalyzed cross-electrophile coupling of halogenated pyridines with secondary alkyl bromides using zinc as the terminal reductant. With this protocol, we have successfully achieved different alkyl-substituted pyridines in modera
An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy
Donald, Craig,Boyd, Scott
, p. 3853 - 3856 (2012/08/13)
We have discovered a novel route for synthesising 2-alkylpyridines by exploiting the decarboxylation of pyridyl malonate esters. Herein we report the synthesis of a number of examples and describe how the reaction was discovered.
