22952-32-5

Basic information

• Product Name: 5-CHLORO-2-METHOXYBENZENESULFONYL CHLORIDE
• Synonyms: 5-CHLORO-2-METHOXYBENZENE-1-SULFONYL CHLORIDE;5-CHLORO-2-METHOXYBENZENESULFONYL CHLORIDE;BUTTPARK 49\07-55;ASISCHEM D48924;5-chloro-2-methoxybenzene-1-sulphonyl chloride;5-Chloro-2-methoxybenzenesulfonyl chloride,98%;5-Chloro-2-methoxybenzenesulphonyl chloride;5-chloro-2-methoxybenzenesulfonyl chloride(SALTDATA: FREE)
• CAS NO: 22952-32-5
• Molecular Formula: C₇H₆Cl₂O₃S
• Molecular Weight: 241.09
• Mol File: 22952-32-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 100-104 °C
• Boiling Point: 344.6 °C at 760mmHg
• Flash Point: 162.2 °C
• Appearance: white crystalline powder
• Density: 1.487 g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 5-CHLORO-2-METHOXYBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-METHOXYBENZENESULFONYL CHLORIDE(22952-32-5)
• EPA Substance Registry System: 5-CHLORO-2-METHOXYBENZENESULFONYL CHLORIDE(22952-32-5)

Safety Data

• Hazard Codes: C
• Statements: 34-29-20/21/22
• Safety Statements: 8-45-36/37/39-26
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 22952-32-5(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C7H6Cl2O3S/c1-12-6-3-2-5(8)4-7(6)13(9,10)11/h2-4H,1H3

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 46170-99-4 4-chloroanisole-2-sulfonic acid 
• 7790-94-5 chlorosulfonic acid 
• 106-48-9 4-chloro-phenol 
• 6470-17-3 1-amino-4-methoxybenzene-3-sulphonic acid 

Downstream Products

• 100871-69-0 1,1'-disulfanediylbis(5-chloro-2-methoxybenzene) 
• 81514-22-9 <β-(chloro-5 methoxy-2 benzenesulfonamido)-ethyl>-4 benzenesulfonamide 
• 364067-04-9 5-chloro-2-methoxy-N-methylbenzenesulfonamide 
• 946120-73-6 4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester 
• 946120-91-8 4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-quinoxaline-1,6-dicarboxylic acid 1-tert-butyl ester 6-ethyl ester 
• 946121-38-6 3-(5-chloro-2-methoxy-benzenesulfonylamino)-4-hydroxy-5-trifluoromethyl-benzoic acid methyl ester 
• 82020-51-7 5-chloro-2-methoxybenzenesulfonamide 

Relevant articles and documents

Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 μM) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 μM), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). B

A novel, flexible strategy to construct privileged dibenzo[b,f][1,4,5]oxathiazepine 5,5-dioxides and their heterocyclic isosteres

Secondary o-hydroxybenzene sulfonamides have been explored as bis-electrophilic partners in a practically simple, atom-economical approach to dibenzo[b,f][1,4,5]oxathiazepine-5,5-dioxides and their heterocyclic analogs, which is an underexplored version o