22996-18-5

Basic information

• Product Name: 4-CHLORO-2-NITROBENZYL ALCOHOL
• Synonyms: 4-CHLORO-2-NITROBENZYL ALCOHOL;2-Nitro-4-chlorobenzenemethanol;4-Chloro-2-nitrobenzyl alcohol,98%;4-Chloro-2-nitrobenzoyl alcohol;(4-chloro-2-nitrophenyl)methanol;(4-chloro-2-nitro-phenyl)methanol;4-Chloro-2-nitrobenzyl alcohol 98%
• CAS NO: 22996-18-5
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• EINECS: 245-374-8
• Product Categories: Alcohol;Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 22996-18-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 90-92 °C(lit.)
• Boiling Point: 306.1 °C at 760 mmHg
• Flash Point: 138.9 °C
• Appearance: white to light yellow crystal powder
• Density: 1.476 g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.57±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-NITROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-NITROBENZYL ALCOHOL(22996-18-5)
• EPA Substance Registry System: 4-CHLORO-2-NITROBENZYL ALCOHOL(22996-18-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 22996-18-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H6ClNO3/c8-6-2-1-5(4-10)3-7(6)9(11)12/h1-3,10H,4H2

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 13292-87-0 dimethyl sulfide borane 
• 144-55-8 sodium hydrogencarbonate 
• 610-57-1 2,4-dinitrobenzyl chloride 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 
• 100-44-7 benzyl chloride 
• 4836-66-2 2,4-dinitrobenzyl alcohol 
• 22996-17-4 (4-amino-2-nitrophenyl)methanol 
• 51420-25-8 4-amino-2-chloro-benzyl alcohol 

Downstream Products

• 232953-53-6 methyl 3-[(2-tetrahydropyranyl)oxy]-2-[(4-methoxybenzenesulfonyl)-(2-nitro-4-chlorobenzyl)amino]propionate 
• 1269005-14-2 5-chloro-2-(2-methylbenzyl)aniline 
• 1269005-12-0 4-chloro-1-(2-methylbenzyl)-2-nitrobenzene 
• 724763-05-7 glutaric acid (4,5-dimethoxy-2-nitrobenzyl) ester (4-chloro-2-nitrobenzyl) ester 
• 52311-59-8 4-chloro-2-nitrobenzyl bromide 
• 77421-11-5 (4-Chloro-2-nitro-phenyl)-methanesulfonyl chloride 
• 938-71-6 4-chloro-2-nitrobenzyl chloride 
• 37585-16-3 (2-amino-4-chlorophenyl)methanol 
• 81729-52-4 N-p-chloro-o-nitrobenzyl-phthalimide 
• 290327-95-6 4-chloro-2-nitro-1-[[(tetrahydro-2H-pyran-2-yl)oxy]methyl]benzene 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 290327-96-7 5-chloro-2-{(tetrahydro-2H-pyran-2-yloxy)methyl}aniline 
• 1051899-17-2 (4-chloro-2-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanol 
• 1051901-23-5 C₁₂H₁₁Cl₂N₃O 

Relevant articles and documents

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Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.