230313-64-1Relevant articles and documents
Preparation of 1,2-substituted benzimidazolesviaa copper-catalyzed three component coupling reaction
Yang, Weiguang,Zhao, Yu,Zhou, Zitong,Li, Li,Cui, Liao,Luo, Hui
, p. 8701 - 8707 (2021)
1,2-Substituted benzimidazoles were prepared by simply stirring a mixture of copper catalysts,N-substitutedo-phenylenediamines, sulfonyl azides and terminal alkynes. Particularly, the intermediateN-sulfonylketenimine occurred with two nucleophilic addition and the sulfonyl group was eliminatedviacyclization. In a way, sulfonyl azides and copper catalysts activated the terminal alkynes to synthesize benzimidazoles.
One-pot synthesis of functionalized benzimidazoles and 1H-pyrimidines via cascade reactions of o-aminoanilines or naphthalene-1,8-diamine with alkynes and p-tolylsulfonyl azide
She, Jin,Jiang, Zheng,Wang, Yanguang
experimental part, p. 2023 - 2027 (2010/03/04)
A one-pot synthesis of functionalized benzimidazoles and 1H-pyrimidines via the cascade reactions of o-aminoanilines or naphthalene-1,8-diamine with terminal alkynes and p-tolylsulfonyl azide is reported. The protocol is efficient and general. Georg Thiem