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2305-13-7

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2305-13-7 Usage

Uses

4-Hydroxy-3-methoxybenzenepropanol is a phenolic compound found in maple syrup and was examined to possess anticancer effects on proliferation, apoptosis and cell cycle arrest of human colon cells.

Definition

ChEBI: A member of class of phenols that is 2-methoxyphenol substituted by a 3-hydroxypropyl group at position 4.

Check Digit Verification of cas no

The CAS Registry Mumber 2305-13-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2305-13:
(6*2)+(5*3)+(4*0)+(3*5)+(2*1)+(1*3)=47
47 % 10 = 7
So 2305-13-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O3/c1-13-10-7-8(3-2-6-11)4-5-9(10)12/h4-5,7,11-12H,2-3,6H2,1H3

2305-13-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name dihydroconiferyl alcohol

1.2 Other means of identification

Product number -
Other names 4-(3-Hydroxypropyl)-2-methoxyphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2305-13-7 SDS

2305-13-7Synthetic route

trans-coniferyl aldehyde
458-36-6

trans-coniferyl aldehyde

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethyl acetate for 1h; Ambient temperature;A 1%
B 99%
guaiacylglycerol-β-guaiacyl ether
7382-59-4

guaiacylglycerol-β-guaiacyl ether

A

2-methoxy-4-n-propylphenol
2785-87-7

2-methoxy-4-n-propylphenol

B

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

C

2-methoxy-phenol
90-05-1

2-methoxy-phenol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; zinc(II) acetate dihydrate In methanol at 225℃; under 26618.1 Torr; Catalytic behavior;A 69%
B 20%
C 98%
With hydrogen In methanol at 260℃; under 22502.3 Torr; for 12h; Catalytic behavior; Temperature; Time;A 43 %Chromat.
B 11 %Chromat.
C 71 %Chromat.
With hydrogen In methanol at 220℃; under 22502.3 Torr; for 8h; Catalytic behavior; Temperature;A 11 %Chromat.
B 44 %Chromat.
C 76 %Chromat.
guaiacylglycerol-β-guaiacyl ether
7382-59-4

guaiacylglycerol-β-guaiacyl ether

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

B

2-methoxy-phenol
90-05-1

2-methoxy-phenol

Conditions
ConditionsYield
With formic acid In water at 120℃; for 3h; Green chemistry;A 93%
B 95%
With palladium 10% on activated carbon; hydrogen In methanol at 225℃; under 26618.1 Torr; Catalytic behavior;A 74%
B 74%
With 10% nickel/activated carbon; hydrogen In 1,4-dioxane at 150℃; under 15001.5 Torr; for 2h; Autoclave;A 7.7%
B 6.4%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With ferrous ammonium sulphate hexahydrate; isopropyl β-D-thiogalactopyranoside In aq. phosphate buffer at 37℃; for 48h;91%
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 4h;90%
With hydrogen; palladium on activated charcoal In ethyl acetate for 3h;55 mg
methyl 3-(4-hydroxy-3-methoxyphenyl)propanoate
56024-44-3

methyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium tetrahydroborate In water for 8h; Ambient temperature;90%
With lithium aluminium tetrahydride In diethyl ether
With lithium borohydride In diethyl ether; toluene for 0.25h; Heating;
With lithium aluminium tetrahydride Reduction;
4-allylguaiacol
97-53-0

4-allylguaiacol

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

B

1-(4-hydroxy-3-methoxyphenyl)-2-propanol
20736-21-4

1-(4-hydroxy-3-methoxyphenyl)-2-propanol

Conditions
ConditionsYield
Stage #1: 4-allylguaiacol With dimethylsulfide borane complex In tetrahydrofuran
Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran
A 84%
B n/a
Stage #1: 4-allylguaiacol With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 2h;
Stage #2: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;
A 80%
B n/a
With sodium hydroxide; tetrabutylammonium boranate; dihydrogen peroxide; methyl iodide 1.) CH2Cl2, reflux, 30 min, 2.) 1.5 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

3-(4-hydroxy-3-methoxyphenyl)acrylic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With whole cell cultures of dichomitus albidofuscus at 24℃; for 72h; Darkness; Microbiological reaction;77%
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran / 1 h / -30 °C
2: H2 / 10percent Pd-charcoal / methanol / 2 h / 1810.02 Torr
View Scheme
With D-Glucose; Escherichia coli endogenous alcohol dehydrogenase; Segniliparus rugosus carboxylic acid reductase; dimethyl sulfoxide; magnesium chloride In aq. phosphate buffer at 30℃; for 18h; pH=7.5; Enzymatic reaction;
guaiacylglycerol-β-guaiacyl ether
7382-59-4

guaiacylglycerol-β-guaiacyl ether

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

B

3-Hydroxy-1-methoxy-2-(2-methoxy-phenoxy)-1-(4-hydroxy-3-methoxy-phenyl)-propan
95316-34-0

3-Hydroxy-1-methoxy-2-(2-methoxy-phenoxy)-1-(4-hydroxy-3-methoxy-phenyl)-propan

C

2-methoxy-phenol
90-05-1

2-methoxy-phenol

Conditions
ConditionsYield
With 10% nickel/activated carbon; hydrogen In methanol at 120℃; under 15001.5 Torr; for 2h; Time; Autoclave;A 7.4%
B 72.8%
C 9.2%
coniferaldehyde
20649-42-7, 458-36-6

coniferaldehyde

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

B

3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde
80638-48-8

3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen for 2h;A 70.4%
B 11.9%
1,3-dihydroxy-1-(4-O-benzyl-3-methoxyphenyl)propane
94824-16-5

1,3-dihydroxy-1-(4-O-benzyl-3-methoxyphenyl)propane

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With hydrogenchloride In water45%
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

A

trans-coniferyl aldehyde
458-36-6

trans-coniferyl aldehyde

B

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With D-glucose In aq. phosphate buffer at 30℃; for 16h; pH=8; Enzymatic reaction;A n/a
B 22%
ethanol
64-17-5

ethanol

ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate
61292-90-8

ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium anschliessendes Kochen mit Wasser;
coniferol
458-35-5

coniferol

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With ethanol; nickel Hydrogenation;
With tetrahydrofuran; palladium Hydrogenation;
With hydroxide; hydrogen; nickel In ethanol
With hydrogen; palladium on activated charcoal In methanol under 1810.02 Torr; for 2h;
3-(4-hydroxy-3-methoxyphenyl)propionic acid
1135-23-5

3-(4-hydroxy-3-methoxyphenyl)propionic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride
Multi-step reaction with 2 steps
1: 98 percent H2SO4
2: LiAlH4 / diethyl ether
View Scheme
ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate
61292-90-8

ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With ethanol; sodium
2-hydroxy-5-(3-hydroxy-propyl)-3-methoxy-benzoic acid

2-hydroxy-5-(3-hydroxy-propyl)-3-methoxy-benzoic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

bis-[3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propyl]-ether
7452-86-0

bis-[3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propyl]-ether

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium hydroxide; nickel at 165℃; under 154457 Torr; Hydrogenation;
3.6-Bis-hydroxymethyl-2.5-bis-<4-hydroxy-3-methoxy-phenyl>-1.4-dithian
5155-65-7

3.6-Bis-hydroxymethyl-2.5-bis-<4-hydroxy-3-methoxy-phenyl>-1.4-dithian

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium hydroxide; nickel In ethylene glycol
Veratrylglycerin-β-dihydroconiferylether

Veratrylglycerin-β-dihydroconiferylether

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium hydroxide at 170℃;
1-(4-hydroxy-3-methoxyphenyl)-2-<4-(ω-hydroxypropyl-2-methoxy)-phenoxy>-propane-1,3-diol
97133-59-0, 135820-77-8, 135820-78-9, 79171-88-3, 2316-18-9

1-(4-hydroxy-3-methoxyphenyl)-2-<4-(ω-hydroxypropyl-2-methoxy)-phenoxy>-propane-1,3-diol

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium sulfide; sodium hydroxide at 135℃;
4-allylguaiacol
97-53-0

4-allylguaiacol

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With sodium hydroxide; dimethylsulfide; borane; dihydrogen peroxide other reagents: borane/THF, 9-borabicyclo<3.3.1>nonane; Multistep reaction;
3-<4-acetoxy-3-methoxy-phenyl>-propionyl chloride

3-<4-acetoxy-3-methoxy-phenyl>-propionyl chloride

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With Trimethyl borate; sodium
maple wood

maple wood

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With ethanol; hydrogen; nickel at 170℃; under 154457 Torr;
diethyl ether
60-29-7

diethyl ether

ω-hydroxypropioguaiacone diacetate
107682-24-6

ω-hydroxypropioguaiacone diacetate

LiAlH4

LiAlH4

A

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

B

3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-1-propanol
3063-86-3

3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-1-propanol

bis-[3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propyl]-ether
7452-86-0

bis-[3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propyl]-ether

aq.-ethanolic NaOH

aq.-ethanolic NaOH

Raney nickel

Raney nickel

A

2-methoxy-4-n-propylphenol
2785-87-7

2-methoxy-4-n-propylphenol

B

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

C

bis-<3-(4-hydroxy-3-methoxy-phenyl)-propyl>-ether

bis-<3-(4-hydroxy-3-methoxy-phenyl)-propyl>-ether

Conditions
ConditionsYield
at 165℃; under 154457 Torr; Hydrogenation;
forest plant material

forest plant material

A

carbon dioxide
124-38-9

carbon dioxide

B

carbon monoxide
201230-82-2

carbon monoxide

C

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With air Oxidation; Formation of xenobiotics; Further byproducts given;
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H+
2: H2 / 10 percent Pd/C
3: LiAlH4
View Scheme
Multi-step reaction with 3 steps
1: aq. HCl / 6 h / Heating
2: H2 / 10percent Pd/C / methanol / 0.5 h / 760 Torr / Ambient temperature
3: LiBH4 / diethyl ether; toluene / 0.25 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / 12 h / Reflux; Inert atmosphere
2: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -78 °C / Inert atmosphere
3: ferrous ammonium sulphate hexahydrate; isopropyl β-D-thiogalactopyranoside / aq. phosphate buffer / 48 h / 37 °C
View Scheme
Methyl ferulate
2309-07-1

Methyl ferulate

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2 / 10 percent Pd/C
2: LiAlH4
View Scheme
Multi-step reaction with 2 steps
1: H2 / 10percent Pd/C / methanol / 0.5 h / 760 Torr / Ambient temperature
2: LiBH4 / diethyl ether; toluene / 0.25 h / Heating
View Scheme
poplar lignin

poplar lignin

A

2-methoxy-4-n-propylphenol
2785-87-7

2-methoxy-4-n-propylphenol

B

4-n-propylsyringol
6766-82-1

4-n-propylsyringol

C

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

Conditions
ConditionsYield
With rhodium on carbon; hydrogen In water at 199.84℃; under 25858.1 Torr; for 1h; Autoclave;
With rhodium on carbon; hydrogen In water at 199.84℃; under 25858.1 Torr; for 4h; Autoclave;
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

3-(3',4'-dihydroxyphenyl)-1-propanol
46118-02-9

3-(3',4'-dihydroxyphenyl)-1-propanol

Conditions
ConditionsYield
With zeolite beta (Zeolyst, CP814C) In water at 250℃; under 37503.8 Torr; for 6h; Reagent/catalyst; Sealed tube; Inert atmosphere;98%
8-methylnonanoic acid
5963-14-4

8-methylnonanoic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

8-methylnonanoic acid 3-(4-hydroxy-3-methoxyphenyl)propyl ester
951221-75-3

8-methylnonanoic acid 3-(4-hydroxy-3-methoxyphenyl)propyl ester

Conditions
ConditionsYield
novozyme 435 at 50℃; for 16h; Enzymatic reaction; Neat (no solvent);95.4%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

allyl bromide
106-95-6

allyl bromide

3-(4-(allyloxy)-3-methoxyphenyl)propan-1-ol
130447-88-0

3-(4-(allyloxy)-3-methoxyphenyl)propan-1-ol

Conditions
ConditionsYield
With potassium carbonate In acetone83%
With potassium carbonate; potassium iodide In acetone Reflux;46%
With ethanol; potassium carbonate
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

ethyl acetate
141-78-6

ethyl acetate

3-(4-hydroxy-3-methoxyphenyl)-propyl acetate
14574-06-2

3-(4-hydroxy-3-methoxyphenyl)-propyl acetate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; silica gel at 20℃; for 9h;80%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

7-methoxy-1-oxaspiro[4.5]deca-6,9-dien-8-one

7-methoxy-1-oxaspiro[4.5]deca-6,9-dien-8-one

Conditions
ConditionsYield
With 1,1,3-trimethyl-3-phenylindan-4',5-dicarboxylic acid In dichloromethane74%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

2-(benzyloxy)-1-bromo-5-ethyl-3-methoxybenzene

2-(benzyloxy)-1-bromo-5-ethyl-3-methoxybenzene

3-(4-(2-(benzyloxy)-5-ethyl-3-methoxyphenoxy)-3-methoxyphenyl)propan-1-ol

3-(4-(2-(benzyloxy)-5-ethyl-3-methoxyphenoxy)-3-methoxyphenyl)propan-1-ol

Conditions
ConditionsYield
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 100℃; for 20h; Glovebox; Sealed tube;74%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methoxy-phenol

4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methoxy-phenol

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane for 24h; silylation; 0 deg C up to RT;55%
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

(E)-3-(4-hydroxy-3-methoxyphenyl)propyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

(E)-3-(4-hydroxy-3-methoxyphenyl)propyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Mitsunobu Displacement; chemoselective reaction;50%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

trans-3,5-dimethoxy-4-hydroxycinnamic acid
530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

(E)-3-(4-hydroxy-3-methoxyphenyl)propyl 3-(4-hydroxy-3,5-dimethoxyphenyl)acrylate

(E)-3-(4-hydroxy-3-methoxyphenyl)propyl 3-(4-hydroxy-3,5-dimethoxyphenyl)acrylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Mitsunobu Displacement; chemoselective reaction;50%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

8-hydroxy-7-methoxy-1-(4-nitrophenyl)-1,3,4,5-tetrahydrobenzo[c]oxepine
960357-41-9

8-hydroxy-7-methoxy-1-(4-nitrophenyl)-1,3,4,5-tetrahydrobenzo[c]oxepine

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; aluminium trichloride In 1,4-dioxane at 20℃; for 168h; oxa-Pictet-Spengler reaction;47%
3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde
80638-48-8

3-(3'-methoxy-4'-hydroxyphenyl)propionaldehyde

Conditions
ConditionsYield
With dimethyl sulfoxide; triethylamine In dichloromethane at 20℃; for 0.5h;27.5%
With coniferyl alcohol dehydrogenase isosyme I from cell free extract of Stretomyces sp. NL15-2K; nicotinamide adenine dinucleotide pH=9.5; Kinetics; Concentration; pH-value; Reagent/catalyst; Glycine-NaOH buffer; Enzymatic reaction;
pyridine
110-86-1

pyridine

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

2-methoxy-1-(4-nitro-benzoyloxy)-4-[3-(4-nitro-benzoyloxy)-propyl]-benzene
22805-51-2

2-methoxy-1-(4-nitro-benzoyloxy)-4-[3-(4-nitro-benzoyloxy)-propyl]-benzene

3-Guaiacylpropanol
2305-13-7

3-Guaiacylpropanol

2-hydroxy-5-(3-hydroxy-propyl)-3-methoxy-benzaldehyde
6245-54-1

2-hydroxy-5-(3-hydroxy-propyl)-3-methoxy-benzaldehyde

Conditions
ConditionsYield
With potassium hydroxide; ethanol; chloroform
Multi-step reaction with 4 steps
1: K2CO3; ethanol
2: 240 °C
3: KOH; water / 170 - 175 °C
4: ozone; ethyl acetate / und Erwaermen des Reaktionsprodukts mit Wasser
View Scheme

2305-13-7Relevant articles and documents

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil

, p. 2379 - 2383 (2017)

Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.

-

Granath,Schuerch

, p. 707,709 (1953)

-

Non-plasmonic Ni nanoparticles catalyzed visible light selective hydrogenolysis of aryl ethers in lignin under mild conditions

Baeyens, Jan,Li, Peifeng,Ouyang, Yixuan,Sarina, Sarina,Su, Haijia,Xiao, Gang,Zhao, Yilin,Zhu, Huai-Yong

supporting information, p. 7780 - 7789 (2021/10/12)

Light-driven catalysis on catalytically versatile group VIII metals, which has been widely used in thermal catalysis, holds great potential in solar-to-chemical conversion. We report a novel photocatalysis process for the selective hydrogenolysis of aryl ethers in lignin on a heterogeneous catalyst of non-precious Ni nanoparticles supported on ZrO2. Three aryl ether bonds in lignin were successfully cleaved under mild conditions with excellent conversion and good to excellent selectivity under visible light irradiation. We also used solar irradiation to demonstrate a significant reduction in the total energy consumption. The light irradiation excited interband transitions in Ni nanoparticles and the resultant energetic electrons enhanced the activity of reductive cleavage of the aryl ethers. Its application potential was illustrated by the depolymerization of dealkaline lignin to give a total monomer yield of 9.84 wt% with vanillin, guaiacol, and apocynin as the three major products.

METHOD OF FORMING MONOMERS AND FURFURAL FROM LIGNOCELLULOSE

-

Page/Page column 19; 21; 22, (2020/06/05)

The present disclosure relates to a method of producing monophenolicmonomers and furfural from lignocellulosic biomass beating the biomass in a solvent together with a zeolite based catalyst.

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