233261-84-2

Basic information

• Product Name: 1-[(2-chlorophenyl)sulfonyl]piperazine
• Synonyms: 1-[(2-chlorophenyl)sulfonyl]piperazine;2-Chlorophenyl piperazin-1-yl sulphone, 1-chloro-2-[(piperazin-1-yl)sulphonyl]benzene
• CAS NO: 233261-84-2
• Molecular Formula: C₁₀H₁₃ClN₂O₂S
• Molecular Weight: 260.74042
• Mol File: 233261-84-2.mol

Chemical Properties

• Melting Point: 63～66℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-[(2-chlorophenyl)sulfonyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2-chlorophenyl)sulfonyl]piperazine(233261-84-2)
• EPA Substance Registry System: 1-[(2-chlorophenyl)sulfonyl]piperazine(233261-84-2)

Safety Data

• Hazardous Substances Data: 233261-84-2(Hazardous Substances Data)

Usage

Chemical class

Sulfonyl piperazine derivative

Potential applications

Medicinal chemistry
Drug development

Studied for

Serotonin receptor agonist
Treatment of neurological and psychiatric disorders

Disorders it may help treat

Anxiety
Depression

Other potential uses

Anti-inflammatory agent
Analgesic agent

Insecticidal activity

Demonstrated against certain pests

Upstream product

• 110-85-0 piperazine 
• 2905-23-9 2-chlorophenylsulfonyl chloride 
• 911643-85-1 C₁₅H₂₁ClN₂O₄S 

Downstream Products

• 1291058-02-0 1-benzo[b]thiophen-3-yl-3-[4-(2-chlorobenzenesulfonyl)piperazin-1-yl]-propan-1-ol 
• 1291057-94-7 1-benzo[b]thiophen-3-yl-3-[4-(2-chlorobenzenesulfonyl)piperazin-1-yl]propane-1-one hydrochloride 
• 1291141-95-1 1-benzo[b]thiophen-3-yl-3-[4-(2-chlorobenzenesulfonyl)piperazin-1-yl]propan-1-one 

Relevant articles and documents

Myricetin derivative containing sulfonyl piperazine as well as preparation method and application thereof

The invention discloses a myricetin derivative containing sulfonyl piperazine as well as a preparation method and application of the myricetin derivative. The structural general formula of the myricetin derivative is shown in the specification, and n is t

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. ory

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

Hydroxysteroid dehydrogenase inhibitors

Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.