23429-04-1

Basic information

• Product Name: 2-Oxazolecarboxylic acid, 5-ethoxy-4-methyl-, ethyl ester
• Synonyms: 2-Oxazolecarboxylic acid, 5-ethoxy-4-methyl-, ethyl ester;ethyl 5-ethoxy-4-methyloxazole-2-carboxylate
• CAS NO: 23429-04-1
• Molecular Formula: C9H13 N O4
• Molecular Weight: 199.2
• Mol File: 23429-04-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 128 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.127±0.06 g/cm3(Predicted)
• PKA: -0.93±0.14(Predicted)
• CAS DataBase Reference: 2-Oxazolecarboxylic acid, 5-ethoxy-4-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolecarboxylic acid, 5-ethoxy-4-methyl-, ethyl ester(23429-04-1)
• EPA Substance Registry System: 2-Oxazolecarboxylic acid, 5-ethoxy-4-methyl-, ethyl ester(23429-04-1)

Safety Data

• Hazardous Substances Data: 23429-04-1(Hazardous Substances Data)

Upstream product

• 23460-73-3 N-ethoxyoxalylalanine ethyl ester 
• 20902-48-1 N-ethoxyoxalyl-α-alanine ethyl ester 

Downstream Products

• 5006-20-2 5-ethoxy-4-methyl-oxazole 

Relevant articles and documents

Method for preparing oxazole carboxylic acid ester

The invention relates to the technical field of organic synthesis of medicines, and discloses a method for preparing oxazole carboxylic acid ester. The method provided by the invention comprises the following steps: in the presence of a catalyst, a dehydrating agent and organic alkali, carrying out cyclization reaction on a compound as shown in a formula (II) to obtain a compound as shown in a formula (I), the catalyst is an imidazole compound; wherein in the formula (I) and the formula (II), R1, R2 and R3 are respectively and independently C1-C6 alkyl groups. According to the method, the imidazole compound is used as the catalyst for preparing the oxazole carboxylic ester, so that the reaction yield can be remarkably improved. In addition, the method provided by the invention is simple in process, does not involve the use of other auxiliaries, does not generate phosphorus-containing wastewater, belongs to a green process, and is beneficial to industrial production.

Method for preparing multi-substitution oxazole compound

The invention discloses a method for preparing a multi-substitution oxazole compound. The method comprises the following steps: in the presence of an acid-binding agent, adding a phosgene, two-phosgene or three-phosgene solution into a solution of a compound of a formula II shown in the specification, and further adding an aid to implement a reaction after the solution is added, so as to obtain the multi-substitution oxazole compound of a formula (I) shown in the specification. By adopting the method, the yield of a product oxazole can be increased, and meanwhile, the content of a byproduct N,N-diethyl formyl chloride can be reduced.

Synthesis method of 4-methyl-5-ethyoxy oxazole

The invention discloses a synthesis method of 4-methyl-5-ethyoxy oxazole. The synthesis method comprises the following steps: sequentially adding methylbenzene, N-ethoxyoxoacetyl alanine ethyl ester,triethylamine and phosphorus oxychloride, and heating for a cyclization reaction; adding water and liquid caustic soda into the product of the cyclization reaction; when the pH value shows alkalinity,performing a saponification reaction; after layering of the saponification reaction product, collecting the lower-layer reactant; adding an aqueous solution of hydrochloric acid into the lower-layerreactant till acidity, and heating for reacting, wherein the lower-layer reactant sequentially experiences acidification and decarboxylation to obtain a product solution generating 4-methyl-5-ethoxy oxazole; neutralizing the product solution with alkali till neutrality, and performing separation and purification to obtain 4-methyl-5-ethoxy oxazole. According to the synthesis method disclosed by the invention, the synthesis technology of 4-methyl-5-ethoxy oxazole is optimized, and the wastewater generated in the technological process is reduced.